Human experimental pain models for assessing the therapeutic efficacy of analgesic drugs

AE Olesen, T Andresen, C Staahl, AM Drewes - Pharmacological reviews, 2012 - ASPET
Pain models in animals have shown low predictivity for analgesic efficacy in humans, and
clinical studies are often very confounded, blurring the evaluation. Human experimental pain …

A comparative study of oxycodone and morphine in a multi-modal, tissue-differentiated experimental pain model

C Staahl, LL Christrup, SD Andersen, L Arendt-Nielsen… - Pain, 2006 - journals.lww.com
Visceral pain can be difficult to treat with classical μ-opioid agonists and it has been suggested
to use opioids with distinct pharmacological profiles. In animal experiments, oxycodone …

Experimental human pain models: a review of standardised methods for preclinical testing of analgesics

C Staahl, AM Drewes - Basic & clinical pharmacology & …, 2004 - Wiley Online Library
Treatment of pain is one of the major challenges in clinical medicine. However, it is often
difficult to evaluate the effect of a treatment, as the many symptoms of the underlying diseases …

Subcutaneous Botulinum toxin type A reduces capsaicin-induced trigeminal pain and vasomotor reactions in human skin

P Gazerani, NS Pedersen, C Staahl, AM Drewes… - PAIN®, 2009 - Elsevier
The present human study aimed at investigating the effect of subcutaneous administration
of Botulinum toxin type A (BoNT/A) on capsaicin-induced trigeminal pain, neurogenic …

The effects of Botulinum Toxin type A on capsaicin-evoked pain, flare, and secondary hyperalgesia in an experimental human model of trigeminal sensitization

P Gazerani, C Staahl, AM Drewes, L Arendt-Nielsen - Pain, 2006 - Elsevier
The trigeminovascular system is involved in migraine. Efficacy of Botulinum Toxin type A (BoNT-A)
in migraine has been investigated in clinical studies but the mechanism of action …

Assessing analgesic actions of opioids by experimental pain models in healthy volunteers–an updated review

C Staahl, AE Olesen, T Andresen… - British journal of …, 2009 - Wiley Online Library
AIM Experimental pain models may help to evaluate the mechanisms of action of analgesics
and target the clinical indications for their use. This review addresses how the efficacy of …

Differential effect of opioids in patients with chronic pancreatitis: an experimental pain study

C Staahl, G Dimcevski, S Due Andersen… - Scandinavian journal …, 2007 - Taylor & Francis
Objective. Animal experiments and clinical observations have indicated a different working
profile of oxycodone compared to morphine, and it has previously been shown that …

Analgesic efficacy of peripheral κ-opioid receptor agonist CR665 compared to oxycodone in a multi-modal, multi-tissue experimental human pain model: selective …

L Arendt-Nielsen, AE Olesen, C Staahl… - The Journal of the …, 2009 - pubs.asahq.org
Background Peripherally selective opioids may be beneficial in visceral pain management
due to absence of centrally mediated side effects. The objectives of this study were: (1) to …

Electroencephalography and analgesics

LP Malver, A Brokjær, C Staahl… - British journal of …, 2014 - Wiley Online Library
To assess centrally mediated analgesic mechanisms in clinical trials with pain patients, objective
standardized methods such as electroencephalography ( EEG ) has many advantages. …

Assessing efficacy of non‐opioid analgesics in experimental pain models in healthy volunteers: an updated review

C Staahl, AE Olesen, T Andresen… - British journal of …, 2009 - Wiley Online Library
AIM Experimental pain models may help to evaluate the mechanisms of analgesics and target
the clinical indications for their use. This review, the second in a series of two, addresses …