User profiles for Charles N. Serhan
 | Charles SerhanBrigham & Women's Hospital Harvard Medical School Verified email at zeus.bwh.harvard.edu Cited by 125458 |
Resolvins: a family of bioactive products of omega-3 fatty acid transformation circuits initiated by aspirin treatment that counter proinflammation signals
Aspirin (ASA) is unique among current therapies because it acetylates cyclooxygenase (COX)-2
enabling the biosynthesis of R-containing precursors of endogenous antiinflammatory …
enabling the biosynthesis of R-containing precursors of endogenous antiinflammatory …
Pro-resolving lipid mediators are leads for resolution physiology
CN Serhan - Nature, 2014 - nature.com
Advances in our understanding of the mechanisms that bring about the resolution of acute
inflammation have uncovered a new genus of pro-resolving lipid mediators that include the …
inflammation have uncovered a new genus of pro-resolving lipid mediators that include the …
Resolvin E1 and protectin D1 activate inflammation-resolution programmes
Resolution of acute inflammation is an active process essential for appropriate host
responses, tissue protection and the return to homeostasis 1 , 2 , 3 . During resolution, specific …
responses, tissue protection and the return to homeostasis 1 , 2 , 3 . During resolution, specific …
Resolving inflammation: dual anti-inflammatory and pro-resolution lipid mediators
Active resolution of acute inflammation is a previously unrecognized interface between
innate and adaptive immunity. Once thought to be a passive process, the resolution of …
innate and adaptive immunity. Once thought to be a passive process, the resolution of …
Resolution of inflammation: the beginning programs the end
CN Serhan, J Savill - Nature immunology, 2005 - nature.com
Acute inflammation normally resolves by mechanisms that have remained somewhat elusive.
Emerging evidence now suggests that an active, coordinated program of resolution …
Emerging evidence now suggests that an active, coordinated program of resolution …
Leukotrienes and lipoxins: structures, biosynthesis, and biological effects
…, SE Dahlen, JĹ Lindgren, CA Rouzer, CN Serhan - Science, 1987 - science.org
… N Serhan is an assistant professor in the Hematology Division, Brigham and Women's
Hospital, Harvard Medical School, Boston, MA 02115, USA CA Rouzer and CN Serhan were …
Hospital, Harvard Medical School, Boston, MA 02115, USA CA Rouzer and CN Serhan were …
Resolution phase of inflammation: novel endogenous anti-inflammatory and proresolving lipid mediators and pathways
CN Serhan - Annu. Rev. Immunol., 2007 - annualreviews.org
Resolution of inflammation and the return of tissues to homeostasis are essential. Efforts to
identify molecular events governing termination of self-limited inflammation uncovered …
identify molecular events governing termination of self-limited inflammation uncovered …
The Concise Guide to PHARMACOLOGY 2021/22: G protein‐coupled receptors
The Concise Guide to PHARMACOLOGY 2021/22 is the fifth in this series of biennial
publications. The Concise Guide provides concise overviews, mostly in tabular format, of the key …
publications. The Concise Guide provides concise overviews, mostly in tabular format, of the key …
Novel functional sets of lipid-derived mediators with antiinflammatory actions generated from omega-3 fatty acids via cyclooxygenase 2–nonsteroidal antiinflammatory …
Aspirin therapy inhibits prostaglandin biosynthesis without directly acting on lipoxygenases,
yet via acetylation of cyclooxygenase 2 (COX-2) it leads to bioactive lipoxins (LXs) epimeric …
yet via acetylation of cyclooxygenase 2 (COX-2) it leads to bioactive lipoxins (LXs) epimeric …
Lipid mediator class switching during acute inflammation: signals in resolution
Leukotrienes (LTs) and prostaglandins (PGs) amplify acute inflammation, whereas lipoxins (LXs)
have unique anti-inflammatory actions. Temporal analyses of these eicosanoids in …
have unique anti-inflammatory actions. Temporal analyses of these eicosanoids in …