The neurotransmitter transporters (NTTs) belonging to the solute carrier 6 (SLC6) gene
family (also referred to as the neurotransmitter-sodium-symporter family or Na + /Cl − -dependent …

The understanding of integral membrane protein (IMP) structure and function is hampered
by the difficulty of handling these proteins. Aqueous solubilization, necessary for many types …

Cocaine is a widely abused substance with psychostimulant effects that are attributed to
inhibition of the dopamine transporter (DAT). We present molecular models for DAT binding of …

Integral membrane proteins (IMPs) are crucial cellular components, mediating the transfer
of material and signals between the environment and the cytoplasm, or between different …

BACKGROUND: (±)-Modafinil has piqued interest as a treatment for attention-deficit/hyperactivity
disorder and stimulant dependence. The R-enantiomer of modafinil might have unique …

Depression is a common mental disorder. The standard medical treatment is the selective
serotonin reuptake inhibitors (SSRIs). All characterized SSRIs are competitive inhibitors of the …

Neurotransmitter:sodium symporters (NSS) 1 mediate sodium-dependent reuptake of
neurotransmitters from the synaptic cleft and are targets for many psychoactive drugs. The crystal …

Cocaine exerts its stimulatory effect by inhibiting the dopamine transporter (DAT). However,
novel benztropine- and rimcazole-based inhibitors show reduced stimulant effects compared …

The serotonin transporter (SERT) controls synaptic serotonin levels and is the primary target
for antidepressants, including selective serotonin reuptake inhibitors (eg (S)-citalopram) …

We describe a new type of synthetic amphiphile that is intended to support biochemical
characterization of intrinsic membrane proteins. Members of this new family displayed favorable …