Populations of cells are almost always heterogeneous in function and fate. To understand
the plasticity of cells, it is vital to measure quantitatively and dynamically the molecular …

Chronotherapeutics aim at treating illnesses according to the endogenous biologic rhythms,
which moderate xenobiotic metabolism and cellular drug response. The molecular clocks …

Uncontrolled cell proliferation is one of the key features leading to cancer. Seminal works in
chronobiology have revealed that disruption of the circadian timing system in mice, either by …

The nuclear factor κB (NF-κB) transcription factor regulates cellular stress responses and
the immune response to infection. NF-κB activation results in oscillations in nuclear NF-κB …

… the ‘‘invasion exponent’’ (Metz et al., 1992; Rand et al., 1994) for a small population of altruists.
… so that Du and Dv vanish if Da, Db and Dd go to zero. If we expand the expression for the …

One of the simplest set of equations for the description of epidemics (the SEIR equations)
has been much studied, and produces reasonable approximations to the dynamics of …

… The research work of DA Rand is supported by the Wolfson Foundation and the UK Science
and Engineering Research Council. We thank the ZAM of the Forschungszentrum Jiilich for …

In individual mammalian cells the expression of some genes such as prolactin is highly
variable over time and has been suggested to occur in stochastic pulses. To investigate the …

With the advent of readily accessible high-power computers it has become relatively easy to
produce simulations of interesting spatial ecologies. Even at this early stage these have …

We present a novel and simple method to numerically calculate Fisher information matrices
for stochastic chemical kinetics models. The linear noise approximation is used to derive …