G protein–coupled receptors (GPCRs) continue to be important discovery targets for the
treatment of type 2 diabetes mellitus (T2DM). Many GPCRs are directly involved in the …

Chronic inflammation is a component of numerous diseases including autoimmune, metabolic,
neurodegenerative, and cancer. The discovery and characterization of specialized pro-…

Here we describe the pharmacologic properties of a series of clinically relevant chemoattractant
receptor-homologous molecules expressed on T-helper type 2 (CRTh2) receptor …

… Darren M Riddy … Darren M Riddy … Subsequent agonist stimulation of cells and
detection steps were carried out as previously described by Riddy et al. (2012). …

… In addition, small subsets of genes encoding for regulatory factors and enzymatic processes
that have been implicated in the pathogenesis of type 2 diabetes mellitus (T2DM) were …

Background Alcohol use disorder (AUD) is a major socioeconomic burden on society, and
current pharmacotherapeutic treatment options are inadequate. Aberrant alcohol use and …

The histamine H 3 receptor is a G protein-coupled receptor (GPCR) drug target that is highly
expressed in the CNS, where it acts as both an auto- and hetero-receptor to regulate …

Specialized proresolving mediators (SPMs) and their cognate G protein-coupled receptors
are implicated in autoimmune disorders, including chronic inflammation, rheumatoid arthritis, …

The human histamine H 3 receptor (hH 3 R) is subject to extensive gene splicing that gives
rise to a large number of functional and nonfunctional isoforms. Despite the general …

Tunicates are evolutionary model organisms bridging the gap between vertebrates and
invertebrates. A genomic sequence in Ciona intestinalis (CiOX) shows high similarity to …