The single most common cause of the withdrawal or restriction of the use of marketed drugs
has been QT-interval prolongation associated with polymorphic ventricular tachycardia, or …

… The term repolarization reserve was introduced by Roden, 70 who explained that normal
cardiac … Roden proposed that lesions in these repolarizing mechanisms that result in reduced …

… P2Y 12 inhibitor at standard dose if clinically indicated and no contraindication Moderated …
d The strength of recommendation for “likely” phenotypes are the same as their respective …

Several excellent guidelines already exist on treating patients who have ventricular
arrhythmias (Table 1). The purpose of this document is to update and combine the previously …

<p id="p001">Immune checkpoint inhibitors have improved clinical outcomes associated with
numerous cancers, but high-grade, immune-related adverse events can occur, particularly …

Breast cancers are complex cellular ecosystems where heterotypic interactions play central
roles in disease progression and response to therapy. However, our knowledge of their …

The Trans-Omics for Precision Medicine (TOPMed) programme seeks to elucidate the genetic
architecture and biology of heart, lung, blood and sleep disorders, with the ultimate goal of …

Motivation: Emergence of genetic data coupled to longitudinal electronic medical records (EMRs)
offers the possibility of phenome-wide association scans (PheWAS) for disease–gene …

Candidate gene and genome-wide association studies (GWAS) have identified genetic variants
that modulate risk for human disease; many of these associations require further study to …

… Cells were supplemented with fresh media every 2 d and used in the transport studies on
the fourth day after plating. Transepithelial resistance was measured in each well using a …