Drug-induced prolongation of the QT interval
DM Roden - New England Journal of Medicine, 2004 - Mass Medical Soc
The single most common cause of the withdrawal or restriction of the use of marketed drugs
has been QT-interval prolongation associated with polymorphic ventricular tachycardia, or …
has been QT-interval prolongation associated with polymorphic ventricular tachycardia, or …
Prevention of torsade de pointes in hospital settings: a scientific statement from the American Heart Association and the American College of Cardiology Foundation
… The term repolarization reserve was introduced by Roden, 70 who explained that normal
cardiac … Roden proposed that lesions in these repolarizing mechanisms that result in reduced …
cardiac … Roden proposed that lesions in these repolarizing mechanisms that result in reduced …
Clinical Pharmacogenetics Implementation Consortium Guideline for CYP2C19 Genotype and Clopidogrel Therapy: 2022 Update
… P2Y 12 inhibitor at standard dose if clinically indicated and no contraindication Moderated …
d The strength of recommendation for “likely” phenotypes are the same as their respective …
d The strength of recommendation for “likely” phenotypes are the same as their respective …
ACC/AHA/ESC 2006 guidelines for management of patients with ventricular arrhythmias and the prevention of sudden cardiac death: a report of the American College …
Several excellent guidelines already exist on treating patients who have ventricular
arrhythmias (Table 1). The purpose of this document is to update and combine the previously …
arrhythmias (Table 1). The purpose of this document is to update and combine the previously …
[HTML][HTML] Fulminant myocarditis with combination immune checkpoint blockade
…, BA Olenchock, AH Lichtman, DM Roden… - … England Journal of …, 2016 - Mass Medical Soc
<p id="p001">Immune checkpoint inhibitors have improved clinical outcomes associated with
numerous cancers, but high-grade, immune-related adverse events can occur, particularly …
numerous cancers, but high-grade, immune-related adverse events can occur, particularly …
A single-cell and spatially resolved atlas of human breast cancers
Breast cancers are complex cellular ecosystems where heterotypic interactions play central
roles in disease progression and response to therapy. However, our knowledge of their …
roles in disease progression and response to therapy. However, our knowledge of their …
[HTML][HTML] Sequencing of 53,831 diverse genomes from the NHLBI TOPMed Program
The Trans-Omics for Precision Medicine (TOPMed) programme seeks to elucidate the genetic
architecture and biology of heart, lung, blood and sleep disorders, with the ultimate goal of …
architecture and biology of heart, lung, blood and sleep disorders, with the ultimate goal of …
PheWAS: demonstrating the feasibility of a phenome-wide scan to discover gene–disease associations
Motivation: Emergence of genetic data coupled to longitudinal electronic medical records (EMRs)
offers the possibility of phenome-wide association scans (PheWAS) for disease–gene …
offers the possibility of phenome-wide association scans (PheWAS) for disease–gene …
Systematic comparison of phenome-wide association study of electronic medical record data and genome-wide association study data
Candidate gene and genome-wide association studies (GWAS) have identified genetic variants
that modulate risk for human disease; many of these associations require further study to …
that modulate risk for human disease; many of these associations require further study to …
The drug transporter P-glycoprotein limits oral absorption and brain entry of HIV-1 protease inhibitors.
…, B Leake, AJ Wood, DM Roden… - The Journal of …, 1998 - Am Soc Clin Investig
… Cells were supplemented with fresh media every 2 d and used in the transport studies on
the fourth day after plating. Transepithelial resistance was measured in each well using a …
the fourth day after plating. Transepithelial resistance was measured in each well using a …