The Adhesion family forms a large branch of the pharmacologically important superfamily of
G protein–coupled receptors (GPCRs). As Adhesion GPCRs increasingly receive attention …

Neurexins are essential presynaptic cell adhesion molecules that are linked to schizophrenia
and autism and are subject to extensive alternative splicing. Here, we used a genetic …

Cellular signaling initiated by Hedgehog binding to Patched1 has profound importance in
mammalian embryogenesis, genetic disease, and cancer. Hedgehog acts as a morphogen to …

C1q-like genes (C1ql1–C1ql4) encode small, secreted proteins that are expressed in differential
patterns in the brain but whose receptors and functions remain unknown. BAI3 protein, …

Primary cilia mediate Hh signalling and mutations in their protein components affect Hh
activity. We show that in mice mutant for a cilia intraflagellar transport (IFT) protein, IFT88/polaris, …

The mammalian brain contains few niches for neural stem cells (NSCs) capable of generating
new neurons, whereas other regions are primarily gliogenic. Here we leverage the spatial …

Holoprosencephaly (HPE) is a clinically heterogeneous developmental anomaly affecting
the CNS and face, in which the embryonic forebrain fails to divide into distinct halves. …

C1ql3 is a secreted neuronal protein that binds to BAI3, an adhesion-class GPCR. C1ql3 is
homologous to other gC1q-domain proteins that control synapse numbers, but a role for …

C1q-like (C1QL) -1, -2, and -3 proteins are encoded by homologous genes that are highly
expressed in brain. C1QLs bind to brain-specific angiogenesis inhibitor 3 (BAI3), an adhesion-…

Growth Arrest Specific Gene 1 (Gas1) has long been regarded as a cell cycle inhibitor of the
G0 to S phase transition. How GAS1, a GPI-anchored plasma membrane protein, directs …