User profiles for David C. Thompson
David C. ThompsonChemical Computing Group Verified email at chemcomp.com Cited by 1242 |
Aldehyde dehydrogenases in cellular responses to oxidative/electrophilicstress
…, BC Jackson, A Matsumoto, DC Thompson… - Free radical biology and …, 2013 - Elsevier
Reactive oxygen species (ROS) are continuously generated within living systems and the
inability to manage ROS load leads to elevated oxidative stress and cell damage. Oxidative …
inability to manage ROS load leads to elevated oxidative stress and cell damage. Oxidative …
Aldehyde dehydrogenase inhibitors: a comprehensive review of the pharmacology, mechanism of action, substrate specificity, and clinical application
V Koppaka, DC Thompson, Y Chen, M Ellermann… - Pharmacological …, 2012 - ASPET
Aldehyde dehydrogenases (ALDHs) belong to a superfamily of enzymes that play a key role
in the metabolism of aldehydes of both endogenous and exogenous derivation. The human …
in the metabolism of aldehydes of both endogenous and exogenous derivation. The human …
Comparison of several molecular docking programs: pose prediction and virtual screening accuracy
JB Cross, DC Thompson, BK Rai… - Journal of chemical …, 2009 - ACS Publications
Molecular docking programs are widely used modeling tools for predicting ligand binding
modes and structure based virtual screening. In this study, six molecular docking programs (…
modes and structure based virtual screening. In this study, six molecular docking programs (…
[HTML][HTML] Update on the aldehyde dehydrogenase gene (ALDH) superfamily
B Jackson, C Brocker, DC Thompson, W Black… - Human genomics, 2011 - Springer
Members of the aldehyde dehydrogenase gene (ALDH) superfamily play an important role
in the enzymic detoxification of endogenous and exogenous aldehydes and in the formation …
in the enzymic detoxification of endogenous and exogenous aldehydes and in the formation …
Role of metabolism in drug-induced idiosyncratic hepatotoxicity
…, MD Mitchell, DC Thompson - Critical reviews in …, 2005 - Taylor & Francis
Rare adverse reactions to drugs that are of unknown etiology, or idiosyncratic reactions, can
produce severe medical complications or even death in patients. Current hypotheses …
produce severe medical complications or even death in patients. Current hypotheses …
The role of hyperosmotic stress in inflammation and disease
C Brocker, DC Thompson, V Vasiliou - Biomolecular concepts, 2012 - degruyter.com
Hyperosmotic stress is an often overlooked process that potentially contributes to a number
of human diseases. Whereas renal hyperosmolarity is a well-studied phenomenon, recent …
of human diseases. Whereas renal hyperosmolarity is a well-studied phenomenon, recent …
ALDH1A isozymes are markers of human melanoma stem cells and potential therapeutic targets
…, MD McCarter, J Wang, R Gonzalez, DC Thompson… - Stem …, 2012 - academic.oup.com
Although the concept of cancer stem cells (CSCs) is well-accepted for many tumors, the
existence of such cells in human melanoma has been the subject of debate. In this study, we …
existence of such cells in human melanoma has been the subject of debate. In this study, we …
SARS-CoV-2 wastewater surveillance data can predict hospitalizations and ICU admissions
…, PG Adamopoulos, J Peccia, DC Thompson… - Science of The Total …, 2022 - Elsevier
We measured SARS-CoV-2 RNA load in raw wastewater in Attica, Greece, by RT-qPCR for
the environmental surveillance of COVID-19 for 6 months. The lag between RNA load and …
the environmental surveillance of COVID-19 for 6 months. The lag between RNA load and …
[HTML][HTML] Update of the human and mouse SERPINgene superfamily
…, M McAndrews, MW Wright, DC Thompson… - Human genomics, 2013 - Springer
The serpin family comprises a structurally similar, yet functionally diverse, set of proteins.
Named originally for their function as serine proteinase inhibitors, many of its members are not …
Named originally for their function as serine proteinase inhibitors, many of its members are not …
[HTML][HTML] COVID-19 vulnerability: the potential impact of genetic susceptibility and airborne transmission
…, DW Nebert, JKV Reichardt, DC Thompson… - Human genomics, 2020 - Springer
The recent coronavirus disease (COVID-19), caused by SARS-CoV-2, is inarguably the
most challenging coronavirus outbreak relative to the previous outbreaks involving SARS-CoV …
most challenging coronavirus outbreak relative to the previous outbreaks involving SARS-CoV …