User profiles for David C. Thompson

David C. Thompson

Chemical Computing Group
Verified email at chemcomp.com
Cited by 1242

Aldehyde dehydrogenases in cellular responses to oxidative/electrophilicstress

…, BC Jackson, A Matsumoto, DC Thompson… - Free radical biology and …, 2013 - Elsevier
Reactive oxygen species (ROS) are continuously generated within living systems and the
inability to manage ROS load leads to elevated oxidative stress and cell damage. Oxidative …

Aldehyde dehydrogenase inhibitors: a comprehensive review of the pharmacology, mechanism of action, substrate specificity, and clinical application

V Koppaka, DC Thompson, Y Chen, M Ellermann… - Pharmacological …, 2012 - ASPET
Aldehyde dehydrogenases (ALDHs) belong to a superfamily of enzymes that play a key role
in the metabolism of aldehydes of both endogenous and exogenous derivation. The human …

Comparison of several molecular docking programs: pose prediction and virtual screening accuracy

JB Cross, DC Thompson, BK Rai… - Journal of chemical …, 2009 - ACS Publications
Molecular docking programs are widely used modeling tools for predicting ligand binding
modes and structure based virtual screening. In this study, six molecular docking programs (…

[HTML][HTML] Update on the aldehyde dehydrogenase gene (ALDH) superfamily

B Jackson, C Brocker, DC Thompson, W Black… - Human genomics, 2011 - Springer
Members of the aldehyde dehydrogenase gene (ALDH) superfamily play an important role
in the enzymic detoxification of endogenous and exogenous aldehydes and in the formation …

Role of metabolism in drug-induced idiosyncratic hepatotoxicity

…, MD Mitchell, DC Thompson - Critical reviews in …, 2005 - Taylor & Francis
Rare adverse reactions to drugs that are of unknown etiology, or idiosyncratic reactions, can
produce severe medical complications or even death in patients. Current hypotheses …

The role of hyperosmotic stress in inflammation and disease

C Brocker, DC Thompson, V Vasiliou - Biomolecular concepts, 2012 - degruyter.com
Hyperosmotic stress is an often overlooked process that potentially contributes to a number
of human diseases. Whereas renal hyperosmolarity is a well-studied phenomenon, recent …

ALDH1A isozymes are markers of human melanoma stem cells and potential therapeutic targets

…, MD McCarter, J Wang, R Gonzalez, DC Thompson… - Stem …, 2012 - academic.oup.com
Although the concept of cancer stem cells (CSCs) is well-accepted for many tumors, the
existence of such cells in human melanoma has been the subject of debate. In this study, we …

SARS-CoV-2 wastewater surveillance data can predict hospitalizations and ICU admissions

…, PG Adamopoulos, J Peccia, DC Thompson… - Science of The Total …, 2022 - Elsevier
We measured SARS-CoV-2 RNA load in raw wastewater in Attica, Greece, by RT-qPCR for
the environmental surveillance of COVID-19 for 6 months. The lag between RNA load and …

[HTML][HTML] Update of the human and mouse SERPINgene superfamily

…, M McAndrews, MW Wright, DC Thompson… - Human genomics, 2013 - Springer
The serpin family comprises a structurally similar, yet functionally diverse, set of proteins.
Named originally for their function as serine proteinase inhibitors, many of its members are not …

[HTML][HTML] COVID-19 vulnerability: the potential impact of genetic susceptibility and airborne transmission

…, DW Nebert, JKV Reichardt, DC Thompson… - Human genomics, 2020 - Springer
The recent coronavirus disease (COVID-19), caused by SARS-CoV-2, is inarguably the
most challenging coronavirus outbreak relative to the previous outbreaks involving SARS-CoV …