[HTML][HTML] Cellular and molecular mechanisms of pain

AI Basbaum, DM Bautista, G Scherrer, D Julius - Cell, 2009 - cell.com
The nervous system detects and interprets a wide range of thermal and mechanical stimuli,
as well as environmental and endogenous chemical irritants. When intense, these stimuli …

The capsaicin receptor: a heat-activated ion channel in the pain pathway

…, M Tominaga, TA Rosen, JD Levine, D Julius - Nature, 1997 - nature.com
Capsaicin, the main pungent ingredient in ‘hot’ chilli peppers, elicits a sensation of burning
pain by selectively activating sensory neurons that convey information about noxious stimuli …

Identification of a cold receptor reveals a general role for TRP channels in thermosensation

DD McKemy, WM Neuhausser, D Julius - Nature, 2002 - nature.com
The cellular and molecular mechanisms that enable us to sense cold are not well understood.
Insights into this process have come from the use of pharmacological agents, such as …

Molecular mechanisms of nociception

D Julius, AI Basbaum - Nature, 2001 - nature.com
The sensation of pain alerts us to real or impending injury and triggers appropriate protective
responses. Unfortunately, pain often outlives its usefulness as a warning system and …

Mustard oils and cannabinoids excite sensory nerve fibres through the TRP channel ANKTM1

…, PM Zygmunt, ED Högestätt, ID Meng, D Julius - Nature, 2004 - nature.com
Wasabi, horseradish and mustard owe their pungency to isothiocyanate compounds. Topical
application of mustard oil (allyl isothiocyanate) to the skin activates underlying sensory …

Vanilloid receptors on sensory nerves mediate the vasodilator action of anandamide

…, H Chuang, M Sørgård, V Di Marzo, D Julius… - Nature, 1999 - nature.com
The endogenous cannabinoid receptor agonist anandamide 1 is a powerful vasodilator of
isolated vascular preparations 2 , 3 , 4 , but its mechanism of action is unclear. Here we show …

[PDF][PDF] The cloned capsaicin receptor integrates multiple pain-producing stimuli

…, K Skinner, BE Raumann, AI Basbaum, D Julius - Neuron, 1998 - cell.com
Capsaicin, the main pungent ingredient in "hot" chili peppers, elicits burning pain by activating
specific (vanilloid) receptors on sensory nerve endings. The cloned vanilloid receptor (…

Lessons from peppers and peppermint: the molecular logic of thermosensation

SE Jordt, DD McKemy, D Julius - Current opinion in neurobiology, 2003 - Elsevier
Sensory neurons report a wide range of temperatures, from noxious heat to noxious cold.
Natural products that elicit psychophysical sensations of hot or cold, such as capsaicin or …

[PDF][PDF] A unified nomenclature for the superfamily of TRP cation channels

…, DE Clapham, C Harteneck, S Heller, D Julius… - Molecular cell, 2002 - cell.com
The TRP superfamily includes a diversity of non-voltagegated cation channels that vary
significantly in their selectivity and mode of activation. Nevertheless, members of the TRP …

A capsaicin-receptor homologue with a high threshold for noxious heat

…, TA Rosen, M Tominaga, AJ Brake, D Julius - Nature, 1999 - nature.com
Pain-producing heat is detected by several classes of nociceptive sensory neuron that differ
in their thermal response thresholds 1 , 2 , 3 . The cloned capsaicin receptor, also known as …