The endothelins comprise three structurally similar 21-amino acid peptides. Endothelin-1
and -2 activate two G-protein coupled receptors, ET A and ET B , with equal affinity, whereas …

Endothelin (ET) peptides and their receptors are intimately involved in the physiological
control of systemic blood pressure and body Na homeostasis, exerting these effects through …

First identified as a powerful vasoconstrictor, endothelin has an extremely diverse set of actions
that influence homeostatic mechanisms throughout the body. Two receptor subtypes, ET …

Background— Vascular damage caused by cerebral ischemia leads to edema, hemorrhage
formation, and worsened outcomes in ischemic stroke patients. Therapeutic interventions …

Endothelin (ET) is a potent vasoactive peptide produced by endothelial cells that elicits
prolonged constriction in most smooth muscle preparations and dilation in others. Of three …

The present study tested the hypothesis that increasing epoxyeicosatrienoic acids by inhibition
of soluble epoxide hydrolase (sEH) would lower blood pressure and ameliorate renal …

Epoxyeicosatrienoic acids (EET) have antihypertensive and anti-inflammatory properties
and play a role in the maintenance of renal vascular function. A novel approach to increase …

Endothelin (ET) receptor blockade delays the progression of diabetic nephropathy; however,
the mechanism of this protection is unknown. Therefore, the aim of this study was to test the …

Table in Reference 28). The difference between selective and mixed antagonists, however,
is not pharmacologically well defined, making antagonist studies difficult to interpret. …

Fructose feeding has been widely reported to cause hypertension in rats, as assessed
indirectly by tail cuff plethysmography. Because there are potentially significant drawbacks …