User profiles for David R. Poyner
David R PoynerAston University Verified email at aston.ac.uk Cited by 9116 |
International Union of Pharmacology. XXXII. The mammalian calcitonin gene-related peptides, adrenomedullin, amylin, and calcitonin receptors
The calcitonin family of peptides comprises calcitonin, amylin, two calcitonin gene-related
peptides (CGRPs), and adrenomedullin. The first calcitonin receptor was cloned in 1991. Its …
peptides (CGRPs), and adrenomedullin. The first calcitonin receptor was cloned in 1991. Its …
Lifting the lid on GPCRs: the role of extracellular loops
…, R Kendrick, RT Logan, DR Poyner… - British journal of …, 2012 - Wiley Online Library
GPCRs exhibit a common architecture of seven transmembrane helices (TMs) linked by
intracellular loops and extracellular loops (ECLs). Given their peripheral location to the site of G‐…
intracellular loops and extracellular loops (ECLs). Given their peripheral location to the site of G‐…
Update on the pharmacology of calcitonin/CGRP family of peptides: IUPHAR Review 25
The calcitonin/CGRP family of peptides includes calcitonin, α and β CGRP, amylin, adrenomedullin
(AM) and adrenomedullin 2/intermedin (AM2/IMD). Their receptors consist of one of …
(AM) and adrenomedullin 2/intermedin (AM2/IMD). Their receptors consist of one of …
GPCR modulation by RAMPs
Our conceptual understanding of the molecular architecture of G-protein coupled receptors (GPCRs)
has transformed over the last decade. Once considered as largely independent …
has transformed over the last decade. Once considered as largely independent …
G-protein coupled receptor solubilization and purification for biophysical analysis and functional studies, in the total absence of detergent
G-protein coupled receptors (GPCRs) constitute the largest class of membrane proteins and
are a major drug target. A serious obstacle to studying GPCR structure/function …
are a major drug target. A serious obstacle to studying GPCR structure/function …
Pharmacological discrimination of calcitonin receptor: receptor activity-modifying protein complexes
…, G Christopoulos, A Christopoulos, DR Poyner… - Molecular …, 2005 - ASPET
Calcitonin (CT) receptors dimerize with receptor activity-modifying proteins (RAMPs) to create
high-affinity amylin (AMY) receptors, but there is no reliable means of pharmacologically …
high-affinity amylin (AMY) receptors, but there is no reliable means of pharmacologically …
Calcitonin gene-related peptide: multiple actions, multiple receptors
DR Poyner - Pharmacology & therapeutics, 1992 - Elsevier
Calcitonin gene-related peptide (CGRP) shows diversity both in its effects and its receptors.
It is likely to have roles as a neurotransmitter, neuromodulator, local hormone and trophic …
It is likely to have roles as a neurotransmitter, neuromodulator, local hormone and trophic …
Regulation of signal transduction by calcitonin gene-related peptide receptors
Calcitonin gene-related peptide (CGRP) plays a pivotal role in migraine, activating its
cognate receptor to initiate intracellular signalling. This atypical receptor comprises a distinct …
cognate receptor to initiate intracellular signalling. This atypical receptor comprises a distinct …
The pharmacology of adrenomedullin 2/intermedin
Adrenomedullin 2 (AM2) or intermedin is a member of the calcitonin gene‐related peptide (CGRP)/calcitonin
family of peptides and was discovered in 2004. Unlike other members of …
family of peptides and was discovered in 2004. Unlike other members of …
Inhibition of iron-catalysed hydroxyl radical formation by inositol polyphosphates: a possible physiological function for myo-inositol hexakisphosphate
1. The ability of myo-inositol polyphosphates to inhibit iron-catalysed hydroxyl radical formation
was studied in a hypoxanthine/xanthine oxidase system [Graf, Empson and Eaton (1987) …
was studied in a hypoxanthine/xanthine oxidase system [Graf, Empson and Eaton (1987) …