User profiles for David R. Poyner

David R Poyner

Aston University
Verified email at aston.ac.uk
Cited by 9116

International Union of Pharmacology. XXXII. The mammalian calcitonin gene-related peptides, adrenomedullin, amylin, and calcitonin receptors

DR Poyner, PM Sexton, I Marshall, DM Smith… - Pharmacological …, 2002 - ASPET
The calcitonin family of peptides comprises calcitonin, amylin, two calcitonin gene-related
peptides (CGRPs), and adrenomedullin. The first calcitonin receptor was cloned in 1991. Its …

Lifting the lid on GPCRs: the role of extracellular loops

…, R Kendrick, RT Logan, DR Poyner… - British journal of …, 2012 - Wiley Online Library
GPCRs exhibit a common architecture of seven transmembrane helices (TMs) linked by
intracellular loops and extracellular loops (ECLs). Given their peripheral location to the site of G‐…

Update on the pharmacology of calcitonin/CGRP family of peptides: IUPHAR Review 25

DL Hay, ML Garelja, DR Poyner… - British journal of …, 2018 - Wiley Online Library
The calcitonin/CGRP family of peptides includes calcitonin, α and β CGRP, amylin, adrenomedullin
(AM) and adrenomedullin 2/intermedin (AM2/IMD). Their receptors consist of one of …

GPCR modulation by RAMPs

DL Hay, DR Poyner, PM Sexton - Pharmacology & therapeutics, 2006 - Elsevier
Our conceptual understanding of the molecular architecture of G-protein coupled receptors (GPCRs)
has transformed over the last decade. Once considered as largely independent …

G-protein coupled receptor solubilization and purification for biophysical analysis and functional studies, in the total absence of detergent

…, N Dekker, TR Dafforn, RM Bill, DR Poyner… - Bioscience …, 2015 - portlandpress.com
G-protein coupled receptors (GPCRs) constitute the largest class of membrane proteins and
are a major drug target. A serious obstacle to studying GPCR structure/function …

Pharmacological discrimination of calcitonin receptor: receptor activity-modifying protein complexes

…, G Christopoulos, A Christopoulos, DR Poyner… - Molecular …, 2005 - ASPET
Calcitonin (CT) receptors dimerize with receptor activity-modifying proteins (RAMPs) to create
high-affinity amylin (AMY) receptors, but there is no reliable means of pharmacologically …

Calcitonin gene-related peptide: multiple actions, multiple receptors

DR Poyner - Pharmacology & therapeutics, 1992 - Elsevier
Calcitonin gene-related peptide (CGRP) shows diversity both in its effects and its receptors.
It is likely to have roles as a neurotransmitter, neuromodulator, local hormone and trophic …

Regulation of signal transduction by calcitonin gene-related peptide receptors

CS Walker, AC Conner, DR Poyner, DL Hay - Trends in pharmacological …, 2010 - cell.com
Calcitonin gene-related peptide (CGRP) plays a pivotal role in migraine, activating its
cognate receptor to initiate intracellular signalling. This atypical receptor comprises a distinct …

The pharmacology of adrenomedullin 2/intermedin

…, DL Hay, R Quirion, DR Poyner - British journal of …, 2012 - Wiley Online Library
Adrenomedullin 2 (AM2) or intermedin is a member of the calcitonin gene‐related peptide (CGRP)/calcitonin
family of peptides and was discovered in 2004. Unlike other members of …

Inhibition of iron-catalysed hydroxyl radical formation by inositol polyphosphates: a possible physiological function for myo-inositol hexakisphosphate

PT Hawkins, DR Poyner, TR Jackson… - Biochemical …, 1993 - portlandpress.com
1. The ability of myo-inositol polyphosphates to inhibit iron-catalysed hydroxyl radical formation
was studied in a hypoxanthine/xanthine oxidase system [Graf, Empson and Eaton (1987) …