User profiles for Doug Stryke
 | Doug StrykeSoftware Architect/Developer, University of California, San Francisco Verified email at ucsf.edu Cited by 7209 |
[HTML][HTML] Clinical metagenomic sequencing for diagnosis of meningitis and encephalitis
…, C Langelier, A Berger, V Douglas… - … England Journal of …, 2019 - Mass Medical Soc
Background Metagenomic next-generation sequencing (NGS) of cerebrospinal fluid (CSF)
has the potential to identify a broad range of pathogens in a single test. Methods In a 1-year, …
has the potential to identify a broad range of pathogens in a single test. Methods In a 1-year, …
Rapid pathogen detection by metagenomic next-generation sequencing of infected body fluids
We developed a metagenomic next-generation sequencing (mNGS) test using cell-free DNA
from body fluids to identify pathogens. The performance of mNGS testing of 182 body fluids …
from body fluids to identify pathogens. The performance of mNGS testing of 182 body fluids …
[HTML][HTML] Rapid metagenomic identification of viral pathogens in clinical samples by real-time nanopore sequencing analysis
…, S Federman, G Yu, P Mbala, V Bres, D Stryke… - Genome medicine, 2015 - Springer
We report unbiased metagenomic detection of chikungunya virus (CHIKV), Ebola virus (EBOV),
and hepatitis C virus (HCV) from four human blood samples by MinION nanopore …
and hepatitis C virus (HCV) from four human blood samples by MinION nanopore …
Sequence diversity and haplotype structure in the human ABCB1 (MDR1, multidrug resistance transporter) gene
…, M Kawamoto, SJ Johns, D Stryke… - Pharmacogenetics …, 2003 - journals.lww.com
Objectives There is increasing evidence that polymorphism of the ABCB1 (MDR1) gene
contributes to interindividual variability in bioavailability and tissue distribution of P-glycoprotein …
contributes to interindividual variability in bioavailability and tissue distribution of P-glycoprotein …
[HTML][HTML] Adeno-associated virus type 2 in US children with acute severe hepatitis
…, C Morales, PE Oluniyi, J Nguyen, J Tan, D Stryke… - Nature, 2023 - nature.com
As of August 2022, clusters of acute severe hepatitis of unknown aetiology in children have
been reported from 35 countries, including the USA 1 , 2 . Previous studies have found …
been reported from 35 countries, including the USA 1 , 2 . Previous studies have found …
A novel outbreak enterovirus D68 strain associated with acute flaccid myelitis cases in the USA (2012–14): a retrospective cohort study
…, G Yu, S Somasekar, S Federman, D Stryke… - The Lancet Infectious …, 2015 - thelancet.com
Background Enterovirus D68 was implicated in a widespread outbreak of severe respiratory
illness across the USA in 2014 and has also been reported sporadically in patients with …
illness across the USA in 2014 and has also been reported sporadically in patients with …
[HTML][HTML] Nanopore DNA sequencing and genome assembly on the International Space Station
We evaluated the performance of the MinION DNA sequencer in-flight on the International
Space Station (ISS), and benchmarked its performance off-Earth against the MinION, Illumina …
Space Station (ISS), and benchmarked its performance off-Earth against the MinION, Illumina …
Laboratory validation of a clinical metagenomic sequencing assay for pathogen detection in cerebrospinal fluid
Metagenomic next-generation sequencing (mNGS) for pan-pathogen detection has been
successfully tested in proof-of-concept case studies in patients with acute illness of unknown …
successfully tested in proof-of-concept case studies in patients with acute illness of unknown …
Evolutionary conservation predicts function of variants of the human organic cation transporter, OCT1
…, LM Mangravite, CC Huang, D Stryke… - Proceedings of the …, 2003 - National Acad Sciences
The organic cation transporter, OCT1, is a major hepatic transporter that mediates the
uptake of many organic cations from the blood into the liver where the compounds may be …
uptake of many organic cations from the blood into the liver where the compounds may be …
The structure–function linkage database
The Structure–Function Linkage Database (SFLD, http://sfld.rbvi.ucsf.edu/ ) is a manually
curated classification resource describing structure–function relationships for functionally …
curated classification resource describing structure–function relationships for functionally …