WNT signaling is an elaborate and complex collection of signal transduction pathways mediated
by multiple signaling molecules. WNT signaling is critically important for developmental …

Echocardiography is a reliable and reproducible method to assess non-invasively cardiac
function in clinical and experimental research. Significant progress in the development of …

Fibrosis is a general term encompassing a plethora of pathologies that span all systems
and is marked by increased deposition of collagen. Injury of variable etiology gives rise to …

AMP-activated protein kinase (AMPK) has been shown to inhibit cardiac hypertrophy. Here,
we show that submaximal AMPK activation blocks cardiomyocyte hypertrophy without …

Myofibroblasts are differentiated fibroblasts that hold a key role in wound healing and
remodeling following myocardial infarction (MI). A large repertoire of stimuli, such as mechanical …

Hyperglycemia (HG) stimulates the production of reactive oxygen species in the heart
through activation of NADPH oxidase 2 (NOX2). This production is independent of glucose …

Addressing factors modulating COVID-19 is crucial since abundant clinical evidence shows
that outcomes are markedly heterogeneous between patients. This requires identifying the …

We have previously demonstrated that systemic AMP-activated protein kinase α1 (AMPKα1)
invalidation enhanced adverse LV remodelling by increasing fibroblast proliferation, while …

This chapter summarizes the implication of AMP-activated protein kinase (AMPK) in the
regulation of various physiological and pathological cellular events of great importance for the …

Background Recent clinical studies suggest that inflammatory mediators have huge potential
in individualized therapy and in efficacy screening and can be utilized as biomarkers for a …