The quantification of cerebral infarction following focal ischemia in the rat: influence of strain, arterial pressure, blood glucose concentration, and age

D Duverger, ET MacKenzie - Journal of Cerebral Blood Flow …, 1988 - journals.sagepub.com
Focal cerebral ischemia was induced by occlusion of the middle cerebral artery in rats. The
volumetric assessment of infarcted tissue, 2 days following occlusion, was calculated from …

The concept of coupling blood flow to brain function: revision required?

…, L Edvinsson, ET MacKenzie - Annals of Neurology …, 1987 - Wiley Online Library
… AM, Mackenzie ET: Cerebral circulatory and metabolic effects of 5-hydroxy tryptamine in
anesthetized baboons. J Physiol (London) 271:721-733, 1977 26. Harper AM, MacKenzie ET: …

Transforming growth factor-β and ischemic brain injury

…, F Docagne, C Ali, O Nicole, ET MacKenzie… - Cellular and molecular …, 2003 - Springer
Necrosis and apoptosis are the two fundamental hallmarks of neuronal death in stroke.
Nevertheless, thrombolysis, by using the recombinant serine protease t-PA, remains until now …

A potential role for erythropoietin in focal permanent cerebral ischemia in mice

…, D Divoux, A Nouvelot, ET MacKenzie… - Journal of Cerebral …, 1999 - journals.sagepub.com
The present study describes, for the first time, a temporal and spatial cellular expression of
erythropoietin (Epo) and Epo receptor (Epo-R) with the evolution of a cerebral infarct after …

The proteolytic activity of tissue-plasminogen activator enhances NMDA receptor-mediated signaling

…, C Ali, I Margaill, P Carmeliet, ET MacKenzie… - Nature medicine, 2001 - nature.com
Tissue-plasminogen activator (t-PA) is now available for the treatment of thrombo-embolic
stroke but adverse effects have been reported in some patients, particularly hemorrhaging. In …

Normobaric hypoxia induces tolerance to focal permanent cerebral ischemia in association with an increased expression of hypoxia-inducible factor-1 and its target …

…, D Divoux, ET MacKenzie… - Journal of Cerebral …, 2002 - journals.sagepub.com
Tolerance to cerebral ischemia is achieved by preconditioning sublethal stresses, such as
ischemia or hypoxia, paradigms in which the decrease of O 2 availability may constitute an …

Neurons and astrocytes express EPO mRNA: oxygen‐sensing mechanisms that involve the redox‐state of the brain

…, A Yvon, D Vivien, I Duchatelle, ET Mackenzie… - Glia, 2000 - Wiley Online Library
Erythropoietin (Epo), the major hormone controling the hypoxia‐induced increase in the
number of erythrocytes, has also a functional role in the brain. However, few data exist as to the …

Effects of acutely induced hypertension in cats on pial arteriolar caliber, local cerebral blood flow, and the blood-brain barrier.

ET MacKenzie, S Strandgaard, DI Graham… - Circulation …, 1976 - Am Heart Assoc
MacKenzie ET, Harper AM: Effects of decreasing arterial pressure on cerebral blood flow
in the baboon; influence of the sympathetic nervous system. Circ Res 37: 550-557, 1975 30. …

Ischemia-induced interleukin-6 as a potential endogenous neuroprotective cytokine against NMDA receptor-mediated excitoxicity in the brain

…, F Docagne, S Lesne, ET MacKenzie… - Journal of Cerebral …, 2000 - journals.sagepub.com
In the brain, the expression of the pleiotropic cytokine interleukin-6 (IL-6) is enhanced in
various chronic or acute central nervous system disorders. However, the significance of IL-6 …

NMDA receptor activation inhibits α-secretase and promotes neuronal amyloid-β production

…, C Ali, C Gabriel, N Croci, ET MacKenzie… - Journal of …, 2005 - Soc Neuroscience
Acute brain injuries have been identified as a risk factor for developing Alzheimer's disease (AD).
Because glutamate plays a pivotal role in these pathologies, we studied the influence …