Kittens given 60 mg/kg of morphine sulfate revealed a 37% decline in brain-stem norepinephrine
and a 64% decline in adrenal epinephrine in 5 hours. These effects were entirely …

METHODS. Administration of drugs. Dogs. Fortyseven adult mongrel dogs were used. An
approximately equal number of males and femnales was placed on each treatment. Morphine …

In the presence of rat liver microsomes and NADPH n-1-octene, n-4-octene and 3-ethyl-2-pentene
were converted to the glycols with no trace of epoxides. Increased substitution of …

Much published work on the metabolism of the barbiturates cannot be accepted as reliable
because of the lack of specificity of the methods of determining the drugs. Colorimetric and …

Mice injected with thiosemicarbazide and sacrificed during a tonic extensor seizure showed
a significantly smaller decrease in brain GABA than was found in animals similarly treated …

The metabolic fate of 5,5-diphenylhydantoin labeled in the 1-position with N 15 was studied
in rats and dogs. After intravenous administration of the drug to either species, more than 48 …

Differential centrifugation of homogenates of human platelets revealed that potassium (K)
and amino acids (AA) were largely free, whereas 5-hydroxytryptamine (5-HT) was bound …

… Maynert’s paper deals with the effect of pronethalol on seizure … Maynert if his studies with
the catecholamines and … Maynert: 1 am very glad you asked that question, because it gives me …

Drugs of the anesthetic-hypnotic type were compared with respect to the development of
acute tolerance in dogs by determining the plasma concentrations of drug at the time of …

METHODS. The labeled barbital was generously furnished by Dr. DL Tabern of the Abbott
Research Laboratories. It contained 13.9 atom per cent excess N”. In order to confirm that …