User profiles for ESTHER O'SHEA
 | Esther O'SheaProfesora de Farmacología, Facultad de Medicina, Universidad Complutense de Madrid Verified email at ucm.es Cited by 5901 |
The pharmacology and clinical pharmacology of 3, 4-methylenedioxymethamphetamine (MDMA,“ecstasy”)
AR Green, AO Mechan, JM Elliott, E O'Shea… - Pharmacological …, 2003 - ASPET
The amphetamine derivative (±)-3,4-methylenedioxymethamphetamine (MDMA, ecstasy) is
a popular recreational drug among young people, particularly those involved in the dance …
a popular recreational drug among young people, particularly those involved in the dance …
The pharmacology of the acute hyperthermic response that follows administration of 3, 4‐methylenedioxymethamphetamine (MDMA,'ecstasy') to rats
AO Mechan, B Esteban, E O'Shea… - British journal of …, 2002 - Wiley Online Library
The pharmacology of the acute hyperthermia that follows 3,4‐methylenedioxymethamphetamine
(MDMA, ‘ecstasy’) administration to rats has been investigated. MDMA (12.5 mg kg −1 …
(MDMA, ‘ecstasy’) administration to rats has been investigated. MDMA (12.5 mg kg −1 …
A review of the mechanisms involved in the acute MDMA (ecstasy)-induced hyperthermic response
The predominant severe acute adverse effect following ingestion of 3,4-methylenedioxymethamphetamine
(MDMA, ecstasy) by recreational users is hyperthermia which can induce …
(MDMA, ecstasy) by recreational users is hyperthermia which can induce …
Acute and long-term effects of MDMA on cerebral dopamine biochemistry and function
Rationale and objectives The majority of experimental and clinical studies on the pharmacology
of 3,4-methylenedioxymethamphetamine (MDMA, ecstasy) tend to focus on its action on …
of 3,4-methylenedioxymethamphetamine (MDMA, ecstasy) tend to focus on its action on …
Disruption of blood–brain barrier integrity in postmortem alcoholic brain: preclinical evidence of TLR4 involvement from a binge‐like drinking model
Inflammatory cytokines and reactive oxygen species are reported to be involved in blood–brain
barrier (BBB) disruption. Because there is evidence that ethanol (EtOH) induces release …
barrier (BBB) disruption. Because there is evidence that ethanol (EtOH) induces release …
Persistent MDMA‐induced dopaminergic neurotoxicity in the striatum and substantia nigra of mice
Acute administration of repeated doses of 3,4‐methylenedioxymethamphetamine (MDMA,
ecstasy) dramatically reduces striatal dopamine (DA) content, tyrosine hydroxylase (TH), and …
ecstasy) dramatically reduces striatal dopamine (DA) content, tyrosine hydroxylase (TH), and …
3, 4-Methylenedioxymethamphetamine induces monoamine release, but not toxicity, when administered centrally at a concentration occurring following a peripherally …
B Esteban, E O'Shea, J Camarero, V Sanchez… - …, 2001 - Springer
Rationale: There is good evidence that 3,4-methylenedioxymethamphetamine (MDMA)-induced
neurotoxicity results from free radical formation. However, it is unclear whether it is the …
neurotoxicity results from free radical formation. However, it is unclear whether it is the …
[HTML][HTML] Selective vulnerability in striosomes and in the nigrostriatal dopaminergic pathway after methamphetamine administration: early loss of TH in striosomes after …
N Granado, S Ares-Santos, E O'Shea… - Neurotoxicity …, 2010 - Springer
Methamphetamine (METH), a commonly abused psychostimulant, causes dopamine
neurotoxicity in humans, rodents, and nonhuman primates. This study examined the selective …
neurotoxicity in humans, rodents, and nonhuman primates. This study examined the selective …
Addiction and the kynurenine pathway: A new dancing couple?
…, R Vidal, MD Gutiérrez-López, E O'Shea… - Pharmacology & …, 2021 - Elsevier
Drug use poses a serious threat to health systems throughout the world and the number of
consumers rises relentlessly every year. The kynurenine pathway, main pathway of …
consumers rises relentlessly every year. The kynurenine pathway, main pathway of …
Studies, using in vivo microdialysis, on the effect of the dopamine uptake inhibitor GBR 12909 on 3,4‐methylenedioxymethamphetamine ('ecstasy')‐induced …
J Camarero, V Sanchez, E O'Shea… - Journal of …, 2002 - Wiley Online Library
The present study examined the mechanisms by which 3,4‐methylenedioxymethamphetamine
(MDMA) produces long‐term neurotoxicity of striatal dopamine neurones in mice and the …
(MDMA) produces long‐term neurotoxicity of striatal dopamine neurones in mice and the …