Glutamate receptor ion channels: structure, regulation, and function
The mammalian ionotropic glutamate receptor family encodes 18 gene products that
coassemble to form ligand-gated ion channels containing an agonist recognition site, a …
coassemble to form ligand-gated ion channels containing an agonist recognition site, a …
Structure, function, and pharmacology of glutamate receptor ion channels
Many physiologic effects of l-glutamate, the major excitatory neurotransmitter in the mammalian
central nervous system, are mediated via signaling by ionotropic glutamate receptors (…
central nervous system, are mediated via signaling by ionotropic glutamate receptors (…
Phosphodiesterases in the CNS: targets for drug development
FS Menniti, WS Faraci, CJ Schmidt - Nature Reviews Drug Discovery, 2006 - nature.com
The therapeutic and commercial success of phosphodiesterase 5 inhibitors such as Viagra,
Levitra and Cialis has sparked renewed interest in the phosphodiesterases as drug …
Levitra and Cialis has sparked renewed interest in the phosphodiesterases as drug …
An innovative design to establish proof of concept of the antidepressant effects of the NR2B subunit selective N-methyl-D-aspartate antagonist, CP-101,606, in …
…, B Baker, S Kolluri, FS Menniti… - Journal of clinical …, 2008 - journals.lww.com
… Drs Landren, Kolluri, and Menniti are employees of Pfizer. Dr Krams is currently an … NR2B
subunit-selective antagonist CP-101,606 (Menniti et al 17 , structure provided in this reference)…
subunit-selective antagonist CP-101,606 (Menniti et al 17 , structure provided in this reference)…
Immunohistochemical localization of PDE10A in the rat brain
…, AH Varghese, RD Williams, PG Wylie, FS Menniti - Brain research, 2003 - Elsevier
PDE10A is a newly identified cAMP/cGMP phosphodiesterase for which mRNA is highly
expressed in the mammalian striatum. In the present study, PDE10A protein and mRNA …
expressed in the mammalian striatum. In the present study, PDE10A protein and mRNA …
Cyclic GMP signaling is involved in the luteinizing hormone-dependent meiotic maturation of mouse oocytes
S Vaccari, JL Weeks, M Hsieh, FS Menniti… - Biology of …, 2009 - academic.oup.com
It is well established that cAMP signaling is an important regulator of the oocyte meiotic cell
cycle. Conversely, the function of cGMP during oocyte maturation is less clear. Herein, we …
cycle. Conversely, the function of cGMP during oocyte maturation is less clear. Herein, we …
Preclinical characterization of selective phosphodiesterase 10A inhibitors: a new therapeutic approach to the treatment of schizophrenia
…, RD Williams, PR Verhoest, FS Menniti - … of Pharmacology and …, 2008 - ASPET
We have recently proposed the hypothesis that inhibition of the cyclic nucleotide
phosphodiesterase (PDE) 10A may represent a new pharmacological approach to the treatment of …
phosphodiesterase (PDE) 10A may represent a new pharmacological approach to the treatment of …
Inhibition of the striatum-enriched phosphodiesterase PDE10A: a novel approach to the treatment of psychosis
…, L Chambers, A Shrikhande, S Wong, FS Menniti… - …, 2006 - Elsevier
Phosphodiesterase 10A (PDE10A) is a recently identified cyclic nucleotide phosphodiesterase
expressed primarily in dopaminoreceptive medium spiny neurons of the striatum. We …
expressed primarily in dopaminoreceptive medium spiny neurons of the striatum. We …
Immunohistochemical localization of phosphodiesterase 10A in multiple mammalian species
TM Coskran, D Morton, FS Menniti… - … of Histochemistry & …, 2006 - journals.sagepub.com
A monoclonal antibody directed against the amino terminal of rat phosphodiesterase 10A (PDE10A)
was used to localize PDE10A in multiple central nervous system (CNS) and …
was used to localize PDE10A in multiple central nervous system (CNS) and …
[HTML][HTML] Turnover of inositol polyphosphate pyrophosphates in pancreatoma cells.
FS Menniti, RN Miller, JW Putney Jr… - Journal of Biological …, 1993 - Elsevier
There is little information concerning the intracellular function of inositol 1,3,4,5,6-pentakis-
and hexakisphosphate, despite their being the most abundant inositol polyphosphates. …
and hexakisphosphate, despite their being the most abundant inositol polyphosphates. …