User profiles for F. Sladek
Frances SladekUniversity of California Riverside Verified email at ucr.edu Cited by 11269 |
The concise guide to PHARMACOLOGY 2015/16: Overview
…, CA Sartorius, DL Segaloff, FM Sladek… - British journal of …, 2015 - Wiley Online Library
The Concise Guide to PHARMACOLOGY 2015/16 provides concise overviews of the key
properties of over 1750 human drug targets with their pharmacology, plus links to an open …
properties of over 1750 human drug targets with their pharmacology, plus links to an open …
International union of pharmacology. LXVI. Orphan nuclear receptors
Half of the members of the nuclear receptors superfamily are so-called “orphan” receptors
because the identity of their ligand, if any, is unknown. Because of their important biological …
because the identity of their ligand, if any, is unknown. Because of their important biological …
What are nuclear receptor ligands?
FM Sladek - Molecular and cellular endocrinology, 2011 - Elsevier
… NRs have variable AF1 and hinge regions and F domains and range in size from ∼450
to ∼933 amino acids, although the majority are ∼50 kDa. Many NR genes have multiple …
to ∼933 amino acids, although the majority are ∼50 kDa. Many NR genes have multiple …
A unified nomenclature system for the nuclear receptor superfamily
…, H Samuels, G Schutz, FM Sladek… - …, 1999 - utsouthwestern.elsevierpure.com
A unified nomenclature system for the nuclear receptor superfamily — University of Texas
Southwestern Medical Center Skip to main navigation Skip to search Skip to main content …
Southwestern Medical Center Skip to main navigation Skip to search Skip to main content …
Liver-enriched transcription factor HNF-4 is a novel member of the steroid hormone receptor superfamily.
FM Sladek, WM Zhong, E Lai… - Genes & …, 1990 - genesdev.cshlp.org
… mine synthetase, which acts in amino acid biosynthesis (CF Kuo and FM Sladek, unpubl.).
Why this factor is involved in regulating this varied assortment of genes is far from obvious. …
Why this factor is involved in regulating this varied assortment of genes is far from obvious. …
Prevalence of the initiator over the TATA box in human and yeast genes and identification of DNA motifs enriched in human TATA-less core promoters
The core promoter of eukaryotic genes is the minimal DNA region that recruits the basal
transcription machinery to direct efficient and accurate transcription initiation. The fraction of …
transcription machinery to direct efficient and accurate transcription initiation. The fraction of …
A transcriptional hierarchy involved in mammalian cell-type specification
CJ Kuo, PB Conley, L Chen, FM Sladek, JE Darnell Jr… - Nature, 1992 - nature.com
ALTHOUGH transcriptional hierachies have been extensively studied in invertebrates, their
involvement in mammalian cell-type specification is poorly understood 1,2 . Here we report a …
involvement in mammalian cell-type specification is poorly understood 1,2 . Here we report a …
Hepatocyte nuclear factor 4α orchestrates expression of cell adhesion proteins during the epithelial transformation of the developing liver
…, AL Gaggl, C Yang, FM Sladek… - Proceedings of the …, 2006 - National Acad Sciences
Epithelial formation is a central facet of organogenesis that relies on intercellular junction
assembly to create functionally distinct apical and basal cell surfaces. How this process is …
assembly to create functionally distinct apical and basal cell surfaces. How this process is …
[HTML][HTML] Identification of an endogenous ligand bound to a native orphan nuclear receptor
Orphan nuclear receptors have been instrumental in identifying novel signaling pathways
and therapeutic targets. However, identification of ligands for these receptors has often been …
and therapeutic targets. However, identification of ligands for these receptors has often been …
AMP-activated protein kinase is involved in endothelial NO synthase activation in response to shear stress
Objective— The regulation of AMP-activated protein kinase (AMPK) is implicated in vascular
biology because AMPK can phosphorylate endothelial NO synthase (eNOS). In this study, …
biology because AMPK can phosphorylate endothelial NO synthase (eNOS). In this study, …