The Concise Guide to PHARMACOLOGY 2015/16 provides concise overviews of the key
properties of over 1750 human drug targets with their pharmacology, plus links to an open …

Half of the members of the nuclear receptors superfamily are so-called “orphan” receptors
because the identity of their ligand, if any, is unknown. Because of their important biological …

… NRs have variable AF1 and hinge regions and F domains and range in size from ∼450
to ∼933 amino acids, although the majority are ∼50 kDa. Many NR genes have multiple …

A unified nomenclature system for the nuclear receptor superfamily — University of Texas
Southwestern Medical Center Skip to main navigation Skip to search Skip to main content …

… mine synthetase, which acts in amino acid biosynthesis (CF Kuo and FM Sladek, unpubl.).
Why this factor is involved in regulating this varied assortment of genes is far from obvious. …

The core promoter of eukaryotic genes is the minimal DNA region that recruits the basal
transcription machinery to direct efficient and accurate transcription initiation. The fraction of …

ALTHOUGH transcriptional hierachies have been extensively studied in invertebrates, their
involvement in mammalian cell-type specification is poorly understood 1,2 . Here we report a …

Epithelial formation is a central facet of organogenesis that relies on intercellular junction
assembly to create functionally distinct apical and basal cell surfaces. How this process is …

Orphan nuclear receptors have been instrumental in identifying novel signaling pathways
and therapeutic targets. However, identification of ligands for these receptors has often been …

Objective— The regulation of AMP-activated protein kinase (AMPK) is implicated in vascular
biology because AMPK can phosphorylate endothelial NO synthase (eNOS). In this study, …