NADPH oxidase-mediated redox signaling: roles in cellular stress response, stress tolerance, and tissue repair
F Jiang, Y Zhang, GJ Dusting - Pharmacological reviews, 2011 - ASPET
NADPH oxidase (Nox) has a dedicated function of generating reactive oxygen species (ROS).
Accumulating evidence suggests that Nox has an important role in signal transduction in …
Accumulating evidence suggests that Nox has an important role in signal transduction in …
[HTML][HTML] NADPH oxidase-dependent redox signaling in TGF-β-mediated fibrotic responses
F Jiang, GS Liu, GJ Dusting, EC Chan - Redox biology, 2014 - Elsevier
Uncontrolled fibrosis in organs like heart, kidney, liver and lung is detrimental and may lead
to end-stage organ failure. Currently there is no effective treatment for fibrotic disorders. …
to end-stage organ failure. Currently there is no effective treatment for fibrotic disorders. …
Regulation of cell proliferation by NADPH oxidase-mediated signaling: potential roles in tissue repair, regenerative medicine and tissue engineering
…, F Jiang, HM Peshavariya, GJ Dusting - Pharmacology & …, 2009 - Elsevier
The superoxide generating enzyme NADPH oxidase has received much attention as a
major cause of oxidative stress underlying vascular disease. However, there is increasing …
major cause of oxidative stress underlying vascular disease. However, there is increasing …
Comparative analysis of paracrine factor expression in human adult mesenchymal stem cells derived from bone marrow, adipose, and dermal tissue
…, A Asgari, Z Lokmic, R Sinclair, GJ Dusting… - Stem cells and …, 2012 - liebertpub.com
Human adult mesenchymal stem cells (MSCs) support the engineering of functional tissue
constructs by secreting angiogenic and cytoprotective factors, which act in a paracrine fashion …
constructs by secreting angiogenic and cytoprotective factors, which act in a paracrine fashion …
Reconstituted high-density lipoproteins inhibit the acute pro-oxidant and proinflammatory vascular changes induced by a periarterial collar in normocholesterolemic …
SJ Nicholls, GJ Dusting, B Cutri, S Bao… - Circulation, 2005 - Am Heart Assoc
Background— HDLs have antiinflammatory and antioxidant properties in vitro. This study
investigates these properties in vivo. Methods and Results— Chow-fed, normocholesterolemic …
investigates these properties in vivo. Methods and Results— Chow-fed, normocholesterolemic …
Direct evidence of a role for Nox2 in superoxide production, reduced nitric oxide bioavailability, and early atherosclerotic plaque formation in ApoE−/− mice
…, AA Miller, S Selemidis, GJ Dusting… - American Journal …, 2010 - journals.physiology.org
The Nox family NADPH oxidases are reactive oxygen species (ROS)-generating enzymes
that are strongly implicated in atherogenesis. However, no studies have examined which Nox …
that are strongly implicated in atherogenesis. However, no studies have examined which Nox …
Hyperpolarization and relaxation of arterial smooth muscle caused by nitric oxide derived from the endothelium
…, HC Parkington, HA Coleman, TO Neild, GJ Dusting - Nature, 1990 - nature.com
STIMULATION of the endothelial lining of arteries with acetyl-choline results in the release of
a diffusible substance that relaxes and hyperpolarizes the underlying smooth muscle 1–9 . …
a diffusible substance that relaxes and hyperpolarizes the underlying smooth muscle 1–9 . …
Differentiation of human adipose‐derived stem cells into beating cardiomyocytes
YS Choi, GJ Dusting, S Stubbs… - Journal of cellular …, 2010 - Wiley Online Library
Human adipose‐derived stem cells (ASCs) may differentiate into cardiomyocytes and this
provides a source of donor cells for tissue engineering. In this study, we evaluated …
provides a source of donor cells for tissue engineering. In this study, we evaluated …
Prostacyclin (PGX) is the endogeneous metabolite responsible for relaxation of coronary arteries induced by arachidonic acid
GJ Dusting, S Moncada, JR Vane - Prostaglandins, 1977 - Elsevier
The actions of prostacyclin (PGX) and several other derivatives of arachidonic acid were
examined on spiral strips of bovine coronary artery. The strips were contracted by PGE 2 and …
examined on spiral strips of bovine coronary artery. The strips were contracted by PGE 2 and …
Analysis of dihydroethidium fluorescence for the detection of intracellular and extracellular superoxide produced by NADPH oxidase
HM Peshavariya, GJ Dusting, S Selemidis - Free radical research, 2007 - Taylor & Francis
All methods used for quantitation of superoxide have limitations when it comes to differentiating
between extracellular and intracellular sites of superoxide production. In the present …
between extracellular and intracellular sites of superoxide production. In the present …