A physiological approach to hepatic drug clearance

GR Wilkinson, DG Shand - Clinical Pharmacology & …, 1975 - Wiley Online Library
… 378 Wilkinson and Shand … 380 Wilkinson and Shand … Shand, DG, Kornhauser, DM,
and Wilkinson, GR: Effects of route of administration on hepatic drug elimination. In press, 1. …

Lorazepam is an independent risk factor for transitioning to delirium in intensive care unit patients

…, GR Wilkinson, RS Dittus, GR Bernard… - The Journal of the …, 2006 - pubs.asahq.org
Background Delirium has recently been shown as a predictor of death, increased cost, and
longer duration of stay in ventilated patients. Sedative and analgesic medications relieve …

Drug metabolism and variability among patients in drug response

GR Wilkinson - New England Journal of Medicine, 2005 - Mass Medical Soc
Differences in drug responsiveness are common, often leading to challenges in optimizing
the dosage regimen for a particular patient. Recent advances provide a rational framework for …

Identification of functionally variant MDR1 alleles among European Americans and African Americans

…, JD Schuetz, EG Schuetz, GR Wilkinson - Clinical …, 2001 - Wiley Online Library
MDR1 (P‐glycoprotein) is an important factor in the disposition of many drugs, and the
involved processes often exhibit considerable interindividual variability that may be genetically …

[HTML][HTML] The major genetic defect responsible for the polymorphism of S-mephenytoin metabolism in humans.

SM De Morais, GR Wilkinson, J Blaisdell… - Journal of Biological …, 1994 - Elsevier
The metabolism of the anticonvulsant drug mephenytoin exhibits a genetic polymorphism in
humans, with the poor metabolizer trait being inherited in an autosomal recessive fashion. …

The drug transporter P-glycoprotein limits oral absorption and brain entry of HIV-1 protease inhibitors.

…, AJ Wood, DM Roden, GR Wilkinson - The Journal of …, 1998 - Am Soc Clin Investig
Currently available HIV-1 protease inhibitors are potent agents in the therapy of HIV-1
infection. However, limited oral absorption and variable tissue distribution, both of which are …

In vitro and in vivo drug interactions involving human CYP3A

KE Thummel, GR Wilkinson - Annual review of pharmacology …, 1998 - annualreviews.org
▪ Abstract Cytochrome P4503A (CYP3A) is importantly involved in the metabolism of many
chemically diverse drugs administered to humans. Moreover, its localization in high amounts …

The effects of age and liver disease on the disposition and elimination of diazepam in adult man.

…, S Schenker, GR Wilkinson - The Journal of …, 1975 - Am Soc Clin Investig
This study investigates the separate effects of age and hepatocellular liver disease on the
disposition and elimination of diazepam (Valium) in man. The drug was given either by rapid …

[PDF][PDF] Identification of a new genetic defect responsible for the polymorphism of (S)-mephenytoin metabolism in Japanese.

SM De Morais, GR Wilkinson, J Blaisdell… - Molecular …, 1994 - Citeseer
A genetic polymorphism in the metabolism of the anticonvulsant drug (S)-mephenytoin has
been well documented in humans. There are marked interracial differences in the frequency …

Pharmacogenetics of efavirenz and central nervous system side effects: an Adult AIDS Clinical Trials Group study

…, HJ Ribaudo, RB Kim, C Tierney, GR Wilkinson… - Aids, 2004 - journals.lww.com
… Forty-seven subjects prematurely discontinued efavirenz-based regimens (n ¼ 23) and/or
experienced highgrade or treatment-limiting central nervous system toxicities (n ¼ 31). There …