Role of Somatodendritic 5‐HT Autoreceptors in Modulating 5‐HT Neurotransmissiona
P Blier, G Pineyro, M El Mansari… - Annals of the New …, 1998 - Wiley Online Library
A very important element controlling serotonin (5‐HT) release throughout the brain is the 5‐HT
1A autoreceptor present on the soma and dendrites of 5‐HT neurons since it exerts a …
1A autoreceptor present on the soma and dendrites of 5‐HT neurons since it exerts a …
Molecular pharmacology of δ-opioid receptors
… Thus, DOPr ligands are examined in terms of structural and functional variety, DOPrs’ capacity
to engage a multiplicity of canonical and noncanonical G protein–dependent responses is …
to engage a multiplicity of canonical and noncanonical G protein–dependent responses is …
Autoregulation of serotonin neurons: role in antidepressant drug action
G Piñeyro, P Blier - Pharmacological reviews, 1999 - ASPET
The existence of an endogenous vasoconstrictor in blood serum (Stevens and Lee, 1984;
Brodie, 1900) and the presence in the gut of a substance that increases intestinal motility (…
Brodie, 1900) and the presence in the gut of a substance that increases intestinal motility (…
[PDF][PDF] Serotonin4 (5-HT4) receptor agonists are putative antidepressants with a rapid onset of action
…, N Haddjeri, G Piñeyro, AF Sadikot, G Debonnel - Neuron, 2007 - cell.com
… two other groups of stressed animals (5.6 versus 6.7–7.1 g) on day À3, ie, before any … g was
still observable on day 10, this time with respect to unchallenged animals (13.4 versus 14.8 g…
still observable on day 10, this time with respect to unchallenged animals (13.4 versus 14.8 g…
Desensitization of the neuronal 5-HT carrier following its long-term blockade
G Pineyro, P Blier, T Dennis… - Journal of …, 1994 - Soc Neuroscience
In vivo extracellular unitary recordings, in vitro 3H-5-hydroxy- tryptamine (5-HT) uptake, and
3H-paroxetine binding assays were used to assess the effect of acute and long-term …
3H-paroxetine binding assays were used to assess the effect of acute and long-term …
[HTML][HTML] Acan downregulation in parvalbumin GABAergic cells reduces spontaneous recovery of fear memories
…, AB Patel, G Andelfinger, G Pineyro, G Di Cristo - Molecular …, 2023 - nature.com
While persistence of fear memories is essential for survival, a failure to inhibit fear in response
to harmless stimuli is a feature of anxiety disorders. Extinction training only temporarily …
to harmless stimuli is a feature of anxiety disorders. Extinction training only temporarily …
[HTML][HTML] … transfer assays reveal ligand-specific conformational changes within preformed signaling complexes containing δ-opioid receptors and heterotrimeric G …
…, M Vallières, PW Schiller, M Bouvier, G Pineyro - Journal of biological …, 2008 - ASBMB
… DORs and α i1 β 1 γ 2 G protein subunits were tagged with Luc or green fluorescent … G
protein interactions from different vantage points. Results showed that DORs and heterotrimeric G …
protein interactions from different vantage points. Results showed that DORs and heterotrimeric G …
[HTML][HTML] Kir3 channel signaling complexes: focus on opioid receptor signaling
K Nagi, G Pineyro - Frontiers in cellular neuroscience, 2014 - frontiersin.org
… This inhibition is partly accomplished by activation of hyperpolarizing G protein-coupled …
neurotransmitters which, upon activation of corresponding G protein-coupled receptors (GPCRs) …
neurotransmitters which, upon activation of corresponding G protein-coupled receptors (GPCRs) …
β-Arrestin-mediated activation of MAPK by inverse agonists reveals distinct active conformations for G protein-coupled receptors
…, T Kohout, M Bouvier, G Piñeyro - Proceedings of the …, 2003 - National Acad Sciences
It is becoming increasingly clear that signaling via G protein-coupled receptors is a diverse
phenomenon involving receptor interaction with a variety of signaling partners. Despite this …
phenomenon involving receptor interaction with a variety of signaling partners. Despite this …
Differential association of receptor-Gβγ complexes with β-arrestin2 determines recycling bias and potential for tolerance of delta opioid receptor agonists
…, M Millecamps, LS Stone, G Pineyro - Journal of …, 2012 - Soc Neuroscience
Opioid tendency to generate analgesic tolerance has been previously linked to biased
internalization. Here, we assessed an alternative possibility; whether tolerance of delta opioid …
internalization. Here, we assessed an alternative possibility; whether tolerance of delta opioid …