Several studies have demonstrated unequivocally that certain nonsteroidal anti‐inflammatory
drugs (NSAIDs) such as sodium salicylate, sulindac, ibuprofen, and flurbiprofen cause anti…

Nonsteroidal antiinflammatory drugs (NSAIDs) appear to reduce the risk of developing
cancer. One mechanism through which NSAIDs act to reduce carcinogenesis is to inhibit the …

Ceramides are a class of sphingolipids that are abundant in cell membranes. They are
important structural components of the membrane but can also act as second messengers in …

The regular use of various nonsteroidal anti‐inflammatory drugs (NSAIDs) was shown to
decrease the incidence of colorectal cancer. This effect is thought to be caused predominantly …

We report that GTP cyclohydrolase (GCH1), the rate-limiting enzyme for tetrahydrobiopterin (BH4)
synthesis, is a key modulator of peripheral neuropathic and inflammatory pain. BH4 is …

Neurological complications are common in COVID-19. Although SARS-CoV-2 has been
detected in patients' brain tissues, its entry routes and resulting consequences are not well …

Despite the diverse chemical structure of aspirin-like drugs, the antinociceptive effect of
NSAIDs is mainly due to their common property of inhibiting cyclooxygenases involved in the …

Pharmacological management of severe chronic pain is difficult to achieve with currently
available analgesic drugs, and remains a large unmet therapeutic need. The synthetic peptide …

Beside their structural role for the cell membrane the family of sphingolipids act as effector
molecules in signal transduction with links to various aspects of cancer initiation, progression …

The liver is the major site of biotransformation for most opioids. Thus, the disposition of these
drugs may be affected in patients with liver insufficiency. The major metabolic pathway for …