Because of the increasing number of immunocompromised patients and due to problems
with antifungal treatment, especially with the most widely used antifungals, azoles, there is an …

Variability of drug metabolism, especially that of the most important phase I enzymes or
cytochrome P450 (CYP) enzymes, is an important complicating factor in many areas of …

The prodrug concept has been used to improve undesirable properties of drugs since the late
19th century, although it was only at the end of the 1950s that the actual term prodrug was …

Detailed knowledge of metabolism of drugs is crucial for two main reasons. First, metabolism
determines to a large extent pharmacokinetic behaviour, interindividual variability and …

Pathogenesis of lung diseases, such as lung cancer and chronic obstructive pulmonary
disease, is tightly linked to exposure to environmental chemicals, most notably tobacco smoke. …

Objective To determine the existence of mutant and variant CYP3A4 alleles in three racial
groups and to assess functions of the variant alleles by complementary deoxyribonucleic acid (…

Coumarin 7-hydroxylation is catalysed by a high-affinity CYP2A6 enzyme in human liver
microsomes. CYP2A6 is the only enzyme catalysing this reaction and consequently the …

Up to 90% of all cancers are possibly caused by environmental factors, such as tobacco
smoke, diet and occupational exposures. The majority of chemical carcinogens require …

A group of human cytochrome P450 genes encompassing the CYP2A, CYP2B, and CYP2F
subfamilies were cloned and assembled into a 350-kb contig localized on the long arm of …

Practically all lipid-soluble xenobiotics enter the conceptus through placental transfer. Many
xenobiotics, including a number of clinically used drugs, are known to cause unwanted …