Fine tuning of sympathetic transmitter release via ionotropic and metabotropic presynaptic receptors

S Boehm, H Kubista - Pharmacological reviews, 2002 - ASPET
The release of transmitters at sympathoeffector junctions is not constant, but subject to
modulation by a plethora of different mechanisms. In this respect, presynaptic receptors located …

[HTML][HTML] The paroxysmal depolarization shift: reconsidering its role in epilepsy, epileptogenesis and beyond

H Kubista, S Boehm, M Hotka - International journal of molecular sciences, 2019 - mdpi.com
Paroxysmal depolarization shifts (PDS) have been described by epileptologists for the first
time several decades ago, but controversy still exists to date regarding their role in epilepsy. …

[HTML][HTML] Rescue by 4-phenylbutyrate of several misfolded creatine transporter-1 variants linked to the creatine transporter deficiency syndrome

…, F Koban, M Hotka, HMM Asjad, H Kubista… - …, 2019 - Elsevier
Diseases arising from misfolding of SLC6 transporters have been reported over recent years,
eg. folding-deficient mutants of the dopamine transporter and of the glycine transporter-2 …

Concomitant facilitation of GABAA receptors and KV7 channels by the non‐opioid analgesic flupirtine

…, A Yousuf, I Salzer, H Kubista… - British journal of …, 2012 - Wiley Online Library
BACKGROUND AND PURPOSE Flupirtine is a non‐opioid analgesic that has been in clinical
use for more than 20 years. It is characterized as a selective neuronal potassium channel …

The anticonvulsant retigabine is a subtype selective modulator of GABAA receptors

…, C Meyer, K Hilber, S Boehm, H Kubista - …, 2015 - Wiley Online Library
Objective Within its range of therapeutic plasma concentrations, the anticonvulsant retigabine
(ezogabine) is believed to selectively act on Kv7 channels. Here, the contribution of …

Lesional antibody synthesis and complement deposition associate with de novo antineuronal antibody synthesis after spinal cord injury

…, T Zrzavy, V Endmayr, G Ricken, H Kubista… - Neurology …, 2023 - AAN Enterprises
Background and Objectives Spinal cord injury (SCI) disrupts the fine-balanced interaction
between the CNS and immune system and can cause maladaptive aberrant immune …

Cardiovascular phenotype of the Dmdmdx rat – a suitable animal model for Duchenne muscular dystrophy

…, D Abraham, H Todt, H Kubista… - Disease Models & …, 2021 - journals.biologists.com
Besides skeletal muscle abnormalities, Duchenne muscular dystrophy (DMD) patients present
with dilated cardiomyopathy development, which considerably contributes to morbidity …

Enhanced currents through L-type calcium channels in cardiomyocytes disturb the electrophysiology of the dystrophic heart

…, S Kummer, RE Bittner, H Kubista… - American Journal …, 2014 - journals.physiology.org
Duchenne muscular dystrophy (DMD), induced by mutations in the gene encoding for the
cytoskeletal protein dystrophin, is an inherited disease characterized by progressive muscle …

[HTML][HTML] Lipid-independent control of endothelial and neuronal TRPC3 channels by light

…, C Klec, C Butorac, WF Graier, H Kubista… - Chemical …, 2019 - pubs.rsc.org
Lipid-gated TRPC channels are highly expressed in cardiovascular and neuronal tissues.
Exerting precise pharmacological control over their activity in native cells is expected to serve …

δ Subunit‐containing GABAA receptors are preferred targets for the centrally acting analgesic flupirtine

…, D Khan, DD Pollak, H Kubista… - British journal of …, 2015 - Wiley Online Library
Background and Purpose The K v 7 channel activator flupirtine is a clinical analgesic
characterized as ‘selective neuronal potassium channel opener’. Flupirtine was found to exert …