Guanylyl cyclases and signaling by cyclic GMP

…, GM Pitari, S Kazerounian, I Ruiz-Stewart… - Pharmacological …, 2000 - ASPET
Guanylyl cyclases are a family of enzymes that catalyze the conversion of GTP to cGMP. The
family comprises both membrane-bound and soluble isoforms that are expressed in nearly …

Proliferative signaling by store-operated calcium channels opposes colon cancer cell cytostasis induced by bacterial enterotoxins

…, FJ Shah, GS Frick, M Madesh, I Ruiz-Stewart… - … of Pharmacology and …, 2005 - ASPET
Guanylyl cyclase C and accumulation of cGMP induced by bacterial heat-stable enterotoxins
(STs) promote colon cancer cell cytostasis, serving as a tumor suppressor in intestine. …

Nitric oxide activation of soluble guanylyl cyclase reveals high and low affinity sites that mediate allosteric inhibition by calcium

S Kazerounian, GM Pitari, I Ruiz-Stewart, S Schulz… - Biochemistry, 2002 - ACS Publications
Cyclic GMP (cGMP) and Ca 2+ regulate opposing mechanisms in (patho)physiological
processes reflected in the reciprocal regulation of their intracellular concentrations. Although …

Soluble guanylate cyclase is allosterically inhibited by direct interaction with 2‐substituted adenine nucleotides

I RuizStewart, S Kazerounian, GM Pitari… - European journal of …, 2002 - Wiley Online Library
Nitric oxide (NO), the principal endogenous ligand for soluble guanylate cyclase (sGC),
stimulates that enzyme and accumulation of intracellular cGMP, which mediates many of the (…

Adenine nucleotide regulation of soluble guanylyl cyclase: Coupling nitric oxide signaling to cell metabolism

I Ruiz-Stewart - 2004 - search.proquest.com
Soluble guanylyl cyclase (sGC), a subtype of the guanylyl cyclase family of enzymes, is
endogenously expressed in many tissue types and is responsible for mediating many (patho) …

[CITATION][C] Phosphorylation of CDX-2 at serine 60 by mitogenic signaling suppresses guanylyl cyclase C expression in human colon carcinoma cells

…, F Boudreau, S Kazerounian, IA Ruiz-Stewart… - Gastroenterology, 2003 - infona.pl
Phosphorylation of CDX-2 at serine 60 by mitogenic signaling suppresses guanylyl cyclase C
expression in human colon carcinoma cells × Close The Infona portal uses cookies, ie strings …

Construction of a novel self-inactivating gene activating vector: Splicing and non-encapsidation of vector RNA

AJ Goodrich - 2004 - search.proquest.com
RNA splicing is a complex event in the retroviral life cycle and can involve multiple steps as
well as cw-acting sequences, to maintain a proper balance of spliced and unspliced viral …

[HTML][HTML] Differential inhibition of adenylyl cyclase isoforms and soluble guanylyl cyclase by purine and pyrimidine nucleotides

A Gille, GH Lushington, TC Mou, MB Doughty… - Journal of Biological …, 2004 - ASBMB
Mammals express nine membranous adenylyl cyclase isoforms (ACs 1–9), a structurally
related soluble guanylyl cyclase (sGC) and a soluble AC (sAC). Moreover, Bacillus anthracis …

Inhibition of heat-stable toxin–induced intestinal salt and water secretion by a novel class of guanylyl cyclase C inhibitors

MJC Bijvelds, M Loos, I Bronsveld… - The Journal of …, 2015 - academic.oup.com
Background. Many enterotoxigenic Escherichia coli strains produce the heat-stable toxin, STa,
which, by activation of the intestinal receptor-enzyme guanylyl cyclase (GC) C, triggers an …

Hyperammonemia inhibits the natriuretic peptide receptor 2 (NPR-2)-mediated cyclic GMP synthesis in the astrocytic compartment of rat cerebral cortex slices

M Zielińska, I Fresko, A Konopacka, V Felipo… - Neurotoxicology, 2007 - Elsevier
The decrease of cyclic GMP (cGMP) level in the brain, contributing to cognitive and memory
deficit in hyperammonemia (HA), has been attributed to the interference of ammonia with the …