Potassium leak channels and the KCNK family of two-P-domain subunits

SAN Goldstein, D Bockenhauer, I O'Kelly… - Nature Reviews …, 2001 - nature.com
With a bang, a new family of potassium channels has exploded into view. Although KCNK
channels were discovered only five years ago, they already outnumber other channel types. …

International Union of Pharmacology. XLI. Compendium of voltage-gated ion channels: potassium channels

…, HA Lester, D McKinnon, CG Nichols, I O'Kelly… - Pharmacological …, 2003 - ASPET
This summary article presents an overview of the molecular relationships among the voltage-gated
potassium channels and a standard nomenclature for them, which is derived from the …

[PDF][PDF] Tandem-pore K+ channels mediate inhibition of orexin neurons by glucose

…, H Alexopoulos, RH Williams, IM Fearon, I O'Kelly… - Neuron, 2006 - cell.com
Glucose-inhibited neurons orchestrate behavior and metabolism according to body energy
levels, but how glucose inhibits these cells is unknown. We studied glucose inhibition of …

Tebentafusp, a TCR/anti-CD3 bispecific fusion protein targeting gp100, potently activated antitumor immune responses in patients with metastatic melanoma

…, R Naidoo, S Stanhope, S Lewis, J Hurst, I O'Kelly… - Clinical Cancer …, 2020 - AACR
Purpose: Tebentafusp is a first-in-class bispecific fusion protein designed to target gp100 (a
melanoma-associated antigen) through a high affinity T-cell receptor (TCR) binding domain …

[HTML][HTML] Forward transport: 14-3-3 binding overcomes retention in endoplasmic reticulum by dibasic signals

I O'kelly, MH Butler, N Zilberberg, SAN Goldstein - Cell, 2002 - cell.com
Proteins with dibasic retention motifs are subject to retrograde transport to endoplasmic
reticulum (ER) by COPI-coated vesicles. As forward transport requires escape from ER retention, …

[PDF][PDF] Rare variants in NR2F2 cause congenital heart defects in humans

…, H Watkins, AM Lucassen, IM O'Kelly… - The American Journal of …, 2014 - cell.com
Congenital heart defects (CHDs) are the most common birth defect worldwide and are a
leading cause of neonatal mortality. Nonsyndromic atrioventricular septal defects (AVSDs) are …

Airway chemotransduction: from oxygen sensor to cellular effector

…, ME Hartness, GJ Searle, P Miller, I O'Kelly… - American journal of …, 2002 - atsjournals.org
The process of sensing, transducing, and acting on environmental cues is critical to normal
physiologic function. Furthermore, dysfunction of this process can lead to the development of …

The catenin p120ctn inhibits Kaiso-mediated transcriptional repression of the β-catenin/TCF target gene matrilysin

CM Spring, KF Kelly, I O'Kelly, M Graham… - Experimental cell …, 2005 - Elsevier
The POZ-zinc finger transcription factor Kaiso was first identified as a specific binding partner
for the Armadillo catenin and cell adhesion cofactor, p120 ctn . Kaiso is a unique POZ …

[HTML][HTML] Altered Expression of Two-Pore Domain Potassium (K2P) Channels in Cancer

S Williams, A Bateman, I O'Kelly - PLoS One, 2013 - journals.plos.org
Potassium channels have become a focus in cancer biology as they play roles in cell
behaviours associated with cancer progression, including proliferation, migration and apoptosis. …

[HTML][HTML] Combined antisense and pharmacological approaches implicate hTASK as an airway O2 sensing K+ channel

ME Hartness, A Lewis, GJ Searle, I O'Kelly… - Journal of Biological …, 2001 - ASBMB
Neuroepithelial bodies act as airway oxygen sensors. The lung carcinoma line H146 is an
established model for neuroepithelial body cells. Although O 2 sensing in both cells is via …