User profiles for J. A. Heinsbroek
Heinsbroek JAUniversity of Alabama at Birmingham Verified email at uab.edu Cited by 2053 |
The nucleus accumbens: mechanisms of addiction across drug classes reflect the importance of glutamate homeostasis
The nucleus accumbens is a major input structure of the basal ganglia and integrates
information from cortical and limbic structures to mediate goal-directed behaviors. Chronic …
information from cortical and limbic structures to mediate goal-directed behaviors. Chronic …
Corticostriatal plasticity, neuronal ensembles, and regulation of drug-seeking behavior
The idea that interconnected neuronal ensembles code for specific behaviors has been around
for decades; however, recent technical improvements allow studying these networks and …
for decades; however, recent technical improvements allow studying these networks and …
Circuit selectivity in drug versus natural reward seeking behaviors
… expressing Cre recombinase in glutamate, GABA or enkephalin neurons in the VP were
virally transduced to express a Gq coupled DREADD construct, as described by Heinsbroek, …
virally transduced to express a Gq coupled DREADD construct, as described by Heinsbroek, …
Coding the direct/indirect pathways by D1 and D2 receptors is not valid for accumbens projections
It is widely accepted that D1 dopamine receptor–expressing striatal neurons convey their
information directly to the output nuclei of the basal ganglia, whereas D2-expressing neurons …
information directly to the output nuclei of the basal ganglia, whereas D2-expressing neurons …
Loss of plasticity in the D2-accumbens pallidal pathway promotes cocaine seeking
Distinct populations of D1- and D2-dopamine receptor-expressing medium spiny neurons (D1-/D2-MSNs)
comprise the nucleus accumbens, and activity in D1-MSNs promotes, …
comprise the nucleus accumbens, and activity in D1-MSNs promotes, …
Accumbens nNOS interneurons regulate cocaine relapse
Relapse to drug use can be initiated by drug-associated cues. The intensity of cue-induced
relapse is correlated with the induction of transient synaptic potentiation (t-SP) at …
relapse is correlated with the induction of transient synaptic potentiation (t-SP) at …
[PDF][PDF] HDAC5 and its target gene, Npas4, function in the nucleus accumbens to regulate cocaine-conditioned behaviors
Individuals suffering from substance-use disorders develop strong associations between the
drug's rewarding effects and environmental cues, creating powerful, enduring triggers for …
drug's rewarding effects and environmental cues, creating powerful, enduring triggers for …
Ventral pallidum is the primary target for accumbens D1 projections driving cocaine seeking
Outputs from the nucleus accumbens (NAc) include projections to the ventral pallidum and
the ventral tegmental area and subtantia nigra in the ventral mesencephalon. The medium …
the ventral tegmental area and subtantia nigra in the ventral mesencephalon. The medium …
Cocaine and sucrose rewards recruit different seeking ensembles in the nucleus accumbens core
…, E Dereschewitz, L Vaccaro, JA Heinsbroek… - Molecular …, 2020 - nature.com
Poorly regulated reward seeking is a central feature of substance use disorder. Recent
research shows that rewarding drug-related experiences induce synchronous activation of a …
research shows that rewarding drug-related experiences induce synchronous activation of a …
Ventromedial prefrontal cortex pyramidal cells have a temporal dynamic role in recall and extinction of cocaine-associated memory
…, DC Rotaru, JA Heinsbroek… - Journal of …, 2013 - Soc Neuroscience
In addicts, associative memories related to the rewarding effects of drugs of abuse can
evoke powerful craving and drug seeking urges, but effective treatment to suppress these …
evoke powerful craving and drug seeking urges, but effective treatment to suppress these …