Purpose Carbonyl reductases (CBRs) catalyze reduction of anthracyclines to cardiotoxic
alcohol metabolites. Polymorphisms in CBR1 and CBR3 influence synthesis of these …

… 3 gene CBR3 and the NAD(P)H:quinone oxidoreductase 1 gene NQO1 in patients who
developed anthracycline‐related congestive heart failure after childhood cancer - Blanco - 2008 …

Over the past few decades, the diagnosis and management of children with various malignancies
have improved tremendously. As a result, there are an increasing number of children …

Purpose The strong dose-dependent association between anthracyclines and cardiomyopathy
is further exacerbated by the co-occurrence of cardiovascular risk factors (diabetes and …

Thioguanine and mercaptopurine are prodrugs requiring conversion into thiopurine
nucleotides to exert cytotoxicity. Thiopurine S-methyltransferase (TPMT), an enzyme subject to …

Purpose Interindividual variability in the dose-dependent association between anthracyclines
and cardiomyopathy suggests that genetic susceptibility could play a role. The current …

Event-free survival for children with acute lymphoblastic leukemia (ALL) now exceeds 80%
in the most effective trials. Failures are due to relapse, toxicity, and second cancers such as …

Pediatric patients with Down syndrome (DS) are at an increased risk of developing certain
cancers. Specifically, patients with DS have a reported 10–20-fold increased risk of …

MLL gene fusions are the hallmark of more than 70% of therapy‐related leukemias (t‐ML)
associated with topoisomerase II inhibitors (eg, etoposide) and cause leukemia in murine …

Drug clearance is often higher in children than in adults, particularly when normalized to body
weight. We previously showed that liver volume normalized to body weight was inversely …