Chemokine receptors comprise a large family of seven transmembrane domain G protein-coupled
receptors differentially expressed in diverse cell types. Biological activities have been …

A family consisting of at least ten distinct novel 8-10 kd cytokines has been identified over the
past 12 years. These cytokines exhibit from 20 to 45% homology in amino acid sequence, …

… In this review, Joost Oppenheim and his colleagues discuss the biochemical characteristics,
gene cloning, cell sources, biological properties and actions of IL-1, and give reasons why …

Defensins contribute to host defense by disrupting the cytoplasmic membrane of microorganisms.
This report shows that human β-defensins are also chemotactic for immature dendritic …

… Oppenheim, Oleg Chertov; Ll-37, the Neutrophil Granule–And Epithelial Cell–Derived …
Chen, JM Wang, and JJ Oppenheim, unpublished observation). We therefore investigated …

Stimulated human monocytes release several proteins thought to play a role in inflammation,
including interleukin 1, tumor necrosis factor, and plasminogen activator. We have purified …

T lymphocyte chemotactic factor (TCF) was purified to homogeneity from the conditioned
media of phytohemagglutinin-stimulated human blood mononuclear leukocytes by a sequence …

β-Defensins are small antimicrobial peptides of the innate immune system produced in
response to microbial infection of mucosal tissue and skin. We demonstrate that murine β-…

The cDNA coding for human monocyte-derived neutrophil-specific chemotactic factor (MDNCF)
was cloned from LPS-stimulated human monocyte mRNA. The cDNA sequence codes …

Although several CXC chemokines have been shown to induce angiogenesis and play roles
in tumor growth, to date, no member of the CC chemokine family has been reported to play …