User profiles for J. J. Renger
John J. Renger, Ph.D.Cerevel Therapeutics Verified email at cerevel.com Cited by 9795 |
International Union of Basic and Clinical Pharmacology. LXXXVI. Orexin receptor function, nomenclature and pharmacology
AL Gotter, AL Webber, PJ Coleman, JJ Renger… - Pharmacological …, 2012 - ASPET
Orexin signaling is essential for normal regulation of arousal and behavioral state control
and represents an attractive target for therapeutics combating insomnia. Alternatively termed …
and represents an attractive target for therapeutics combating insomnia. Alternatively termed …
Discovery and development of orexin receptor antagonists as therapeutics for insomnia
Insomnia persistently affects the quality and quantity of sleep. Currently approved treatments
for insomnia primarily target γ‐aminobutyric acid‐ A ( GABA‐A ) receptor signalling and …
for insomnia primarily target γ‐aminobutyric acid‐ A ( GABA‐A ) receptor signalling and …
The discovery of suvorexant, the first orexin receptor drug for insomnia
Historically, pharmacological therapies have used mechanisms such as γ-aminobutyric acid
A (GABA A ) receptor potentiation to drive sleep through broad suppression of central …
A (GABA A ) receptor potentiation to drive sleep through broad suppression of central …
Improved stability of Drosophila larval neuromuscular preparations in haemolymph-like physiological solutions
Neuromuscular preparations from third instar larvae of Drosophila are not well-maintained in
commonly used physiological solutions: vacuoles form in the muscle fibers, and membrane …
commonly used physiological solutions: vacuoles form in the muscle fibers, and membrane …
Discovery of the Dual Orexin Receptor Antagonist [(7R)-4-(5-Chloro-1,3-benzoxazol-2-yl)-7-methyl-1,4-diazepan-1-yl][5-methyl-2-(2H-1,2,3-triazol-2-yl)phenyl] …
Despite increased understanding of the biological basis for sleep control in the brain, few
novel mechanisms for the treatment of insomnia have been identified in recent years. One …
novel mechanisms for the treatment of insomnia have been identified in recent years. One …
Promotion of sleep by suvorexant—a novel dual orexin receptor antagonist
…, DR Reiss, D Cui, PJ Coleman, JJ Renger - Journal of …, 2011 - Taylor & Francis
Orexins/hypocretins are key neuropeptides responsible for regulating central arousal and
reward circuits. Two receptors respond to orexin signaling, orexin 1 receptor (OX 1 R) and …
reward circuits. Two receptors respond to orexin signaling, orexin 1 receptor (OX 1 R) and …
Essential thalamic contribution to slow waves of natural sleep
Slow waves represent one of the prominent EEG signatures of non-rapid eye movement (non-REM)
sleep and are thought to play an important role in the cellular and network plasticity …
sleep and are thought to play an important role in the cellular and network plasticity …
Internalized tau oligomers cause neurodegeneration by inducing accumulation of pathogenic tau in human neurons derived from induced pluripotent stem cells
…, NG Hatcher, J Schachter, JJ Renger… - Journal of …, 2015 - Soc Neuroscience
Neuronal inclusions of hyperphosphorylated and aggregated tau protein are a pathological
hallmark of several neurodegenerative tauopathies, including Alzheimer's disease (AD). The …
hallmark of several neurodegenerative tauopathies, including Alzheimer's disease (AD). The …
Selective T-type calcium channel block in thalamic neurons reveals channel redundancy and physiological impact of ITwindow
…, A Tscherter, AC Errington, JJ Renger… - Journal of …, 2010 - Soc Neuroscience
Although it is well established that low-voltage-activated T-type Ca 2+ channels play a key
role in many neurophysiological functions and pathological states, the lack of selective and …
role in many neurophysiological functions and pathological states, the lack of selective and …
Presynaptic HCN1 channels regulate CaV3.2 activity and neurotransmission at select cortical synapses
The hyperpolarization-activated cyclic nucleotide–gated (HCN) channels are subthreshold,
voltage-gated ion channels that are highly expressed in hippocampal and cortical pyramidal …
voltage-gated ion channels that are highly expressed in hippocampal and cortical pyramidal …