[HTML][HTML] Autophagy-mediated tumor promotion
Mouse models for cancer are revealing novel cancer-promoting roles for autophagy. Autophagy
promotes tumor growth by suppressing the p53 response, maintaining mitochondrial …
promotes tumor growth by suppressing the p53 response, maintaining mitochondrial …
[HTML][HTML] The sirtuin family in health and disease
…, YS Liu, G Zheng, JQ Zhao, YF Wei, JY Guo… - Signal transduction and …, 2022 - nature.com
Sirtuins (SIRTs) are nicotine adenine dinucleotide(+)-dependent histone deacetylases
regulating critical signaling pathways in prokaryotes and eukaryotes, and are involved in …
regulating critical signaling pathways in prokaryotes and eukaryotes, and are involved in …
[HTML][HTML] Predictive and mechanistic multivariate linear regression models for reaction development
CB Santiago, JY Guo, MS Sigman - Chemical science, 2018 - pubs.rsc.org
Multivariate Linear Regression (MLR) models utilizing computationally-derived and
empirically-derived physical organic molecular descriptors are described in this review. Several …
empirically-derived physical organic molecular descriptors are described in this review. Several …
Activated Ras requires autophagy to maintain oxidative metabolism and tumorigenesis
Autophagy is a catabolic pathway used by cells to support metabolism in response to starvation
and to clear damaged proteins and organelles in response to stress. We report here that …
and to clear damaged proteins and organelles in response to stress. We report here that …
Size-dependent melting properties of small tin particles: nanocalorimetric measurements
For the first time, the latent heat of fusion Δ H m for Sn particles formed by evaporation on
inert substrate with radii ranging from 5 to 50 nm has been measured directly using a novel …
inert substrate with radii ranging from 5 to 50 nm has been measured directly using a novel …
A comprehensive analysis of built environment characteristics on household residential choice and auto ownership levels
There has been an increasing interest in the land use-transportation connection in the past
decade, motivated by the possibility that design policies associated with the built …
decade, motivated by the possibility that design policies associated with the built …
Autophagy suppresses progression of K-ras-induced lung tumors to oncocytomas and maintains lipid homeostasis
Macroautophagy (autophagy hereafter) degrades and recycles proteins and organelles to
support metabolism and survival in starvation. Oncogenic Ras up-regulates autophagy, and …
support metabolism and survival in starvation. Oncogenic Ras up-regulates autophagy, and …
Autophagy is required for glucose homeostasis and lung tumor maintenance
G Karsli-Uzunbas, JY Guo, S Price, X Teng, SV Laddha… - Cancer discovery, 2014 - AACR
Macroautophagy (autophagy hereafter) recycles intracellular components to sustain
mitochondrial metabolism that promotes the growth, stress tolerance, and malignancy of lung …
mitochondrial metabolism that promotes the growth, stress tolerance, and malignancy of lung …
Comprehensive econometric microsimulator for daily activity-travel patterns
… Bhat CR, Srinivasan S., and Guo JY Activity-Based Travel-Demand Modeling for Metropolitan
Areas in Texas: Model Components and Mathematical Formulations. Research Report …
Areas in Texas: Model Components and Mathematical Formulations. Research Report …
Slow TCA flux and ATP production in primary solid tumours but not metastases
Tissues derive ATP from two pathways—glycolysis and the tricarboxylic acid (TCA) cycle
coupled to the electron transport chain. Most energy in mammals is produced via TCA …
coupled to the electron transport chain. Most energy in mammals is produced via TCA …