User profiles for Jason J. Yi

Jason Yi

Washington University School of Medicine
Verified email at wustl.edu
Cited by 1267

[HTML][HTML] TGF-β signaling specifies axons during brain development

JY Jason, AP Barnes, R Hand, F Polleux, MD Ehlers - Cell, 2010 - cell.com
In the mammalian brain, the specification of a single axon and multiple dendrites occurs
early in the differentiation of most neuron types. Numerous intracellular signaling events for …

Emerging roles for ubiquitin and protein degradation in neuronal function

JY Jason, MD Ehlers - Pharmacological reviews, 2007 - ASPET
Alterations in cellular structure and synapse composition are central to proper nervous
system function. Recent work has identified the ubiquitin-proteasome system (UPS) as a key …

[HTML][HTML] An autism-linked mutation disables phosphorylation control of UBE3A

JY Jason, J Berrios, JM Newbern, WD Snider… - Cell, 2015 - cell.com
Deletion of UBE3A causes the neurodevelopmental disorder Angelman syndrome (AS), while
duplication or triplication of UBE3A is linked to autism. These genetic findings suggest that …

[PDF][PDF] Ubiquitin and protein turnover in synapse function

JY Jason, MD Ehlers - Neuron, 2005 - cell.com
Enduring modification of synapses is central to long-lasting neural circuit plasticity. Such
adaptations include rapid posttranslational modification of existing synaptic proteins over …

Manipulation of endogenous kinase activity in living cells using photoswitchable inhibitory peptides

JJ Yi, H Wang, M Vilela, G Danuser… - ACS synthetic …, 2014 - ACS Publications
Optogenetic control of endogenous signaling can be an important tool for probing cell
behavior. Using the photoresponse of the LOV2 domain of Avena sativa phototropin 1, we …

[HTML][HTML] Activity-induced remodeling of olfactory bulb microcircuits revealed by monosynaptic tracing

BR Arenkiel, H Hasegawa, JJ Yi, RS Larsen… - PloS one, 2011 - journals.plos.org
The continued addition of new neurons to mature olfactory circuits represents a remarkable
mode of cellular and structural brain plasticity. However, the anatomical configuration of …

[HTML][HTML] The autism-linked UBE3A T485A mutant E3 ubiquitin ligase activates the Wnt/β-catenin pathway by inhibiting the proteasome

JY Jason, SR Paranjape, MP Walker… - Journal of Biological …, 2017 - ASBMB
UBE3A is a HECT domain E3 ubiquitin ligase whose dysfunction is linked to autism,
Angelman syndrome, and cancer. Recently, we characterized a de novo autism-linked UBE3A …

Human striatal glia differentially contribute to AD-and PD-specific neurodegeneration

…, Y Shi, WC Knight, RJ Bateman, TLS Benzinger, JJ Yi… - Nature aging, 2023 - nature.com
The commonalities and differences in cell-type-specific pathways that lead to Alzheimer
disease (AD) and Parkinson disease (PD) remain unknown. Here, we performed a single-…

[PDF][PDF] Autism-linked UBE3A gain-of-function mutation causes interneuron and behavioral phenotypes when inherited maternally or paternally in mice

L Xing, JM Simon, TS Ptacek, JY Jason, L Loo, H Mao… - Cell reports, 2023 - cell.com
The E3 ubiquitin ligase Ube3a is biallelically expressed in neural progenitors and glial cells,
suggesting that UBE3A gain-of-function mutations might cause neurodevelopmental …

Dissecting motility signaling through activation of specific Src-effector complexes

…, M Berginski, PH Chu, ED Trudeau, JJ Yi… - Nature chemical …, 2014 - nature.com
We describe an approach to selectively activate a kinase in a specific protein complex or at a
specific subcellular location within living cells and within minutes. This reveals the effects of …