User profiles for Jason J. Yi
Jason YiWashington University School of Medicine Verified email at wustl.edu Cited by 1267 |
[HTML][HTML] TGF-β signaling specifies axons during brain development
In the mammalian brain, the specification of a single axon and multiple dendrites occurs
early in the differentiation of most neuron types. Numerous intracellular signaling events for …
early in the differentiation of most neuron types. Numerous intracellular signaling events for …
Emerging roles for ubiquitin and protein degradation in neuronal function
JY Jason, MD Ehlers - Pharmacological reviews, 2007 - ASPET
Alterations in cellular structure and synapse composition are central to proper nervous
system function. Recent work has identified the ubiquitin-proteasome system (UPS) as a key …
system function. Recent work has identified the ubiquitin-proteasome system (UPS) as a key …
[HTML][HTML] An autism-linked mutation disables phosphorylation control of UBE3A
Deletion of UBE3A causes the neurodevelopmental disorder Angelman syndrome (AS), while
duplication or triplication of UBE3A is linked to autism. These genetic findings suggest that …
duplication or triplication of UBE3A is linked to autism. These genetic findings suggest that …
[PDF][PDF] Ubiquitin and protein turnover in synapse function
JY Jason, MD Ehlers - Neuron, 2005 - cell.com
Enduring modification of synapses is central to long-lasting neural circuit plasticity. Such
adaptations include rapid posttranslational modification of existing synaptic proteins over …
adaptations include rapid posttranslational modification of existing synaptic proteins over …
Manipulation of endogenous kinase activity in living cells using photoswitchable inhibitory peptides
Optogenetic control of endogenous signaling can be an important tool for probing cell
behavior. Using the photoresponse of the LOV2 domain of Avena sativa phototropin 1, we …
behavior. Using the photoresponse of the LOV2 domain of Avena sativa phototropin 1, we …
[HTML][HTML] Activity-induced remodeling of olfactory bulb microcircuits revealed by monosynaptic tracing
The continued addition of new neurons to mature olfactory circuits represents a remarkable
mode of cellular and structural brain plasticity. However, the anatomical configuration of …
mode of cellular and structural brain plasticity. However, the anatomical configuration of …
[HTML][HTML] The autism-linked UBE3A T485A mutant E3 ubiquitin ligase activates the Wnt/β-catenin pathway by inhibiting the proteasome
UBE3A is a HECT domain E3 ubiquitin ligase whose dysfunction is linked to autism,
Angelman syndrome, and cancer. Recently, we characterized a de novo autism-linked UBE3A …
Angelman syndrome, and cancer. Recently, we characterized a de novo autism-linked UBE3A …
Human striatal glia differentially contribute to AD-and PD-specific neurodegeneration
The commonalities and differences in cell-type-specific pathways that lead to Alzheimer
disease (AD) and Parkinson disease (PD) remain unknown. Here, we performed a single-…
disease (AD) and Parkinson disease (PD) remain unknown. Here, we performed a single-…
[PDF][PDF] Autism-linked UBE3A gain-of-function mutation causes interneuron and behavioral phenotypes when inherited maternally or paternally in mice
The E3 ubiquitin ligase Ube3a is biallelically expressed in neural progenitors and glial cells,
suggesting that UBE3A gain-of-function mutations might cause neurodevelopmental …
suggesting that UBE3A gain-of-function mutations might cause neurodevelopmental …
Dissecting motility signaling through activation of specific Src-effector complexes
We describe an approach to selectively activate a kinase in a specific protein complex or at a
specific subcellular location within living cells and within minutes. This reveals the effects of …
specific subcellular location within living cells and within minutes. This reveals the effects of …