G protein coupled receptors (GPCRs) were first characterized as signal transducers that elicit
downstream effects through modulation of guanine (G) nucleotide-binding proteins. The …

Aortic stiffness is a hallmark of cardiovascular disease, but its pathophysiology remains
incompletely understood. This study presents an in-dept characterization of aortic aging in male …

Sclerostin is a well-known inhibitor of bone formation that acts on Wnt/β-catenin signaling.
This manuscript considers the possible role of sclerostin in vascular calcification, a process …

10.7554/eLife.39234.001 Cells constantly adapt to environmental fluctuations. These
physiological changes require time and therefore cause a lag phase during which the cells do not …

… Author links open overlay panel Jhana O. Hendrickx a , Sofie De Moudt a , Elke Calus b ,
Peter Paul De Deyn b c , … MH Sivakumaran, AK Mackenzie, IR Callan, JA Ainge, AR O’Connor …

The average age of the world’s elderly population is steadily increasing. This unprecedented
rise in the aged world population will increase the prevalence of age-related disorders …

Aging is a complex biological process that is inevitable for nearly all organisms. Aging is the
strongest risk factor for development of multiple neurodegenerative disorders, cancer and …

G protein-coupled receptors (GPCRs) and their associated proteins represent one of the most
diverse cellular signaling systems involved in both physiological and pathophysiological …

Increasing epidemiological evidence highlights the association between systemic insulin
resistance and Alzheimer’s disease (AD). As insulin resistance can be caused by high-stress …

Introduction and Aims: Endothelial nitric oxide synthase (eNOS) knockout mice develop
pronounced cardiovascular disease. In the present study, we describe the alterations in aortic …