Coronavirus disease 2019 (COVID-19), caused by a strain of coronavirus known as severe
acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has become a global pandemic …

Existing methods for human induced pluripotent stem cell (hiPSC) cardiac differentiation are
efficient but require complex, undefined medium constituents that hinder further elucidation …

Disease models are essential for understanding cardiovascular disease pathogenesis and
developing new therapeutics. The human induced pluripotent stem cell (iPSC) technology …

Introduction Several lines of evidence point to a key role for dynamic epigenetic changes
during brain development, maturation, and learning. DNA methylation (mC) is a stable covalent …

Since the advent of induced pluripotent stem cell (iPSC) technology a decade ago, enormous
progress has been made in stem cell biology and regenerative medicine. Human iPSCs …

A series of dipyridodiazepinones have been shown to be potent inhibitors of human
immunodeficiency virus-1 (HIV-1) reverse transcriptase (RT). One compound, BI-RG-587, had a K i …

Owing to the risk of insertional mutagenesis, viral transduction has been increasingly replaced
by nonviral methods to generate induced pluripotent stem cells (iPSCs). We report the …

Three groups of young, healthy males underwent positron emission tomography of the head,
using 18 fluoro-2-deoxyglucose as the uptake tracer. During the uptake, one group (n = 8) …

Cardiovascular disease is a leading cause of death worldwide. The limited capability of
heart tissue to regenerate has prompted methodological developments for creating de novo …

Characterized by ventricular dilatation, systolic dysfunction, and progressive heart failure,
dilated cardiomyopathy (DCM) is the most common form of cardiomyopathy in patients. DCM is …