The actions of benzodiazepines are due to the potentiation of the neural inhibition that is
mediated by gamma-aminobutyric acid (GABA). Practically all effects of the benzodiazepines …

Finns are living longer and longer. During the next 20 years, the over 75-year-old population
will almost double from the current 440,000 to about 850,000. By the year 2040, their …

We have studied the pharmacokinetics and pharmacodynamics of alfentanil, fentanyl and
sufentanil together with propofol in patients undergoing coronary artery bypass graft surgery (…

Pregabalin has anticonvulsant, antihyperalgesic, and anxiolytic properties. In this study we
evaluated the control of pain after perioperative administration of pregabalin 300 or 600mg, …

We studied the interaction of azole antimycotics with intravenous (IV) and oral midazolam
using a cross-over design in 12 volunteers, who ingested placebo, itraconazole, or fluconazole …

Background Multimodal pain management has been suggested to improve postoperative
analgesia. In this study, we evaluated the quality of analgesia in women undergoing day-case …

The treatment of life-threatening post-partum haemorrhage (PPH) still remains challenging,
and hysterectomy may be required to control the bleeding. We present 12 cases of severe …

OBJECTIVE: To collect data from nine European countries for cases of obstetric hemorrhage
between 2000 and 2004 in which recombinant activated factor VII (rFVIIa) was used. …

GABA is the major inhibitory neurotransmitter in the central nervous system (CNS). The type
A GABA receptor (GABA A R) system is the primary pharmacological target for many drugs …

BACKGROUND: Apart from being antiemetic, glucocorticoids have an analgesic property.
The optimal dose of dexamethasone in the management of pain after surgery has not been …