5-HT receptor regulation of neurotransmitter release

KB Fink, M Göthert - Pharmacological reviews, 2007 - ASPET
Serotoninergic neurons in the central nervous system impinge on many other neurons and
modulate their neurotransmitter release. This review focuses on 1) the function of presynaptic …

Minocycline inhibits caspase-1 and caspase-3 expression and delays mortality in a transgenic mouse model of Huntington disease

M Chen, VO Ona, M Li, RJ Ferrante, KB Fink, S Zhu… - Nature medicine, 2000 - nature.com
Huntington disease is an autosomal dominant neurodegenerative disease with no effective
treatment. Minocycline is a tetracycline derivative with proven safety. After ischemia, …

Expression of a dominant negative mutant of interleukin-1β converting enzyme in transgenic mice prevents neuronal cell death induced by trophic factor withdrawal …

…, V Gagliardini, H Hara, KB Fink… - The Journal of …, 1997 - rupress.org
… Hara, and KB Fink were supported by a grant from the National Institute of Neurological …
Hara, and KB Fink were supported by a grant from the National Institute of Neurological …

Physical activity improves long-term stroke outcome via endothelial nitric oxide synthase–dependent augmentation of neovascularization and cerebral blood flow

K Gertz, J Priller, G Kronenberg, KB Fink… - Circulation …, 2006 - Am Heart Assoc
Physical activity upregulates endothelial nitric oxide synthase (eNOS), improves endothelium
function, and protects from vascular disease. Here, we tested whether voluntary running …

Neuroprotective effects of atorvastatin against glutamate‐induced excitotoxicity in primary cortical neurones

…, U Dirnagl, H Hörtnagl, KB Fink… - Journal of …, 2005 - Wiley Online Library
Statins [3‐hydroxy‐3‐methylglutaryl‐coenzyme A (HMG‐CoA) reductase inhibitors] exert
cholesterol‐independent pleiotropic effects that include anti‐thrombotic, anti‐inflammatory, and …

Inhibition of histone deacetylation protects wildtype but not gelsolin-deficient mice from ischemic brain injury

…, K Gertz, G Kronenberg, C Harms, KB Fink… - Experimental …, 2008 - Elsevier
Acetylation/deactylation of histones is an important mechanism to regulate gene expression
and chromatin remodeling. We have previously demonstrated that the HDAC inhibitor …

17β-estradiol regulates nNOS and eNOS activity in the hippocampus

…, M Van Eickels, H Vetter, R Meyer, KB Fink - …, 2004 - journals.lww.com
Estrogen treatment in symptomatic postmenopausal women appears to improve cognitive
performance including memory, an effect which may involve enhanced nitric oxide formation …

Increasing myocardial contraction and blood pressure in C57BL/6 mice during early postnatal development

…, R Meyer, C Grohé, KB Fink - American Journal …, 2003 - journals.physiology.org
Knowledge of the developmental changes of cardiovascular parameters in the genetic
background of a mouse strain is important for understanding phenotypic changes in transgenic or …

Reduction of post-traumatic brain injury and free radical production by inhibition of the caspase-1 cascade

KB Fink, LJ Andrews, WE Butler, VO Ona, M Li… - Neuroscience, 1999 - Elsevier
Necrotic and apoptotic cell death both play a role mediating tissue injury following brain
trauma. Caspase-1 (interleukin-1β converting enzyme) is activated and oligonucleosomal DNA …

Impact of actin filament stabilization on adult hippocampal and olfactory bulb neurogenesis

…, R Hellweg, H Kettenmann, KB Fink… - Journal of …, 2010 - Soc Neuroscience
Rearrangement of the actin cytoskeleton is essential for dynamic cellular processes. Decreased
actin turnover and rigidity of cytoskeletal structures have been associated with aging …