The gene encoding the serotonin transporter (5-HTT) contains a regulatory variation that
has been associated with anxiety-related traits and susceptibility for depression. Here we …

… Bengel, D., Murphy, DL, Andrews, AM, Wichems, CH, Feltner, D., Heils, A., Mossner, R.,
Westphal, H., and Lesch, KP Altered brain serotonin homeostasis and locomotor insensitivity to 3…

Attention-deficit/hyperactivity disorder (ADHD) is highly heritable and the most common
neurodevelopmental disorder in childhood. In recent decades, it has been appreciated that in a …

Transporter-facilitated uptake of serotonin (5-hydroxytryptamine or 5-HT) has been implicated
in anxiety in humans and animal models and is the site of action of widely used uptake-…

Mood, emotion, cognition, and motor functions as well as circadian and neuroendocrine
rhythms, including food intake, sleep, and reproductive activity, are modulated by the midbrain …

Attention deficit/hyperactivity disorder (ADHD) is a highly heritable childhood behavioral
disorder affecting 5% of children and 2.5% of adults. Common genetic variants contribute …

The gene encoding the human serotonin transporter (5-HTT) has been isolated and characterized.
The human 5-HTT gene is composed of 14 exons spanning ∼ 31 kb. The sequence …

Genetic influences on psychiatric disorders transcend diagnostic boundaries, suggesting
substantial pleiotropy of contributing loci. However, the nature and mechanisms of these …

Background Neuroimaging studies have shown structural alterations in several brain regions
in children and adults with attention deficit hyperactivity disorder (ADHD). Through the …

The serotonin transporter (5-HTT) is a candidate locus for aetiological involvement in
affective disorders. Biochemical studies in suicides and depressed patients suggest that 5-HT …