The neurotransmitter transporters (NTTs) belonging to the solute carrier 6 (SLC6) gene
family (also referred to as the neurotransmitter-sodium-symporter family or Na + /Cl − -dependent …

… , 73 Recently, more-accurate X-ray crystal structures of GA (1), GC (3), and GJ (4) obtained
at 120 K 74 showed that the overall conclusions regarding the structure of the ginkgolides …

… , University of Copenhagen, where he studied interactions of antidepressants with the
serotonin and norepinephrine transporters under the supervision of Professor Kristian Strømgaard…

… Kristian Strømgaard is a professor of chemical biology in the Department of Medicinal
Chemistry, Faculty of Pharmaceutical Sciences, at the University of Copenhagen. He received his …

… 1B), was obtained with K d of 10 nM towards tandem PDZ1-2 of PSD-95 (20, 21). We here
redesigned the PEG linker, and synthesized a unique PEG-based linker, termed NPEG (…

… The inhibitor bound the PICK1 PDZ domain with an affinity similar to that observed for
endogenous peptide ligands (K i ~10.1 μM). Mutational analysis, together with computational …

… A conservative mutation of Ser-438 to threonine (S438T) selectively increased the K i values
for these antidepressants up to 175-fold. The effects of introducing a protein methyl group …

Glycine and γ-aminobutyric acid, type A (GABA A ) receptors are members of the ligand-gated
ion channel superfamily that mediate inhibitory synaptic transmission in the adult central …

… K d and K i values are given if otherwise not stated. ND, not determined. … Thus, FSC231
was pursued further and shown to bind PICK1 with a K i of 10.1 µm, that is, in the same range as …

The serotonin transporter (SERT) regulates extracellular levels of the neurotransmitter
serotonin (5-hydroxytryptamine) in the brain by facilitating uptake of released 5-hydroxytryptamine …