[PDF][PDF] Structure of the angiotensin receptor revealed by serial femtosecond crystallography

…, TA White, C Wang, A Ishchenko, KC Tirupula… - Cell, 2015 - cell.com
Angiotensin II type 1 receptor (AT 1 R) is a G protein-coupled receptor that serves as a primary
regulator for blood pressure maintenance. Although several anti-hypertensive drugs have …

International Union of Basic and Clinical Pharmacology. XCIX. Angiotensin receptors: interpreters of pathophysiological angiotensinergic stimuli

SS Karnik, H Unal, JR Kemp, KC Tirupula… - Pharmacological …, 2015 - ASPET
The renin angiotensin system (RAS) produced hormone peptides regulate many vital body
functions. Dysfunctional signaling by receptors for RAS peptides leads to pathologic states. …

[HTML][HTML] Atypical signaling and functional desensitization response of MAS receptor to peptide ligands

KC Tirupula, R Desnoyer, RC Speth, SS Karnik - PLoS One, 2014 - journals.plos.org
MAS is a G protein-coupled receptor (GPCR) implicated in multiple physiological processes.
Several physiological peptide ligands such as angiotensin-(1–7), angiotensin fragments …

[PDF][PDF] Click chemistry on azidoproline: high-affinity dual antagonist for HIV-1 envelope glycoprotein gp120

HN Gopi, KC Tirupula, S Baxter, S Ajith, IM Chaiken - ChemMedChem, 2006 - Citeseer
Materials: All Fmoc-protected amino acids, HBTU, HOBt and Hyp (OMe). HCl were purchased
from Novabiochem. Fmoc-PAL-PEG-PS resin was obtained from AppliedBiosystem. …

pH‐dependent Interaction of Rhodopsin with Cyanidin‐3‐glucoside. 2. Functional Aspects

KC Tirupula, F Balem, N Yanamala… - Photochemistry and …, 2009 - Wiley Online Library
Anthocyanins are a class of phytochemicals that confer color to flowers, fruits, vegetables
and leaves. They are part of our regular diet and serve as dietary supplements because of …

G protein-coupled receptors directly bind filamin A with high affinity and promote filamin phosphorylation

KC Tirupula, SS Ithychanda, ML Mohan… - Biochemistry, 2015 - ACS Publications
Although interaction of a few G protein-coupled receptors (GPCRs) with Filamin A, a key
actin cross-linking and biomechanical signal transducer protein, has been observed, a …

[HTML][HTML] Preferential binding of allosteric modulators to active and inactive conformational states of metabotropic glutamate receptors

N Yanamala, KC Tirupula, J Klein-Seetharaman - BMC bioinformatics, 2008 - Springer
Metabotropic glutamate receptors (mGluRs) are G protein coupled receptors that play
important roles in synaptic plasticity and other neuro-physiological and pathological processes. …

pH‐dependent Interaction of Rhodopsin with Cyanidin‐3‐glucoside. 1. Structural Aspects

N Yanamala, KC Tirupula, F Balem… - Photochemistry and …, 2009 - Wiley Online Library
Anthocyanins are a class of natural compounds common in flowers and vegetables. Because
of the increasing preference of consumers for food containing natural colorants and the …

Characterization of membrane protein non-native states. 1. Extent of unfolding and aggregation of rhodopsin in the presence of chemical denaturants

A Dutta, KC Tirupula, U Alexiev… - Biochemistry, 2010 - ACS Publications
Little is known about the general folding mechanisms of helical membrane proteins. Unfolded,
ie, non-native states, in particular, have not yet been characterized in detail. Here, we …

[HTML][HTML] A mechanism of global shape-dependent recognition and phosphorylation of filamin by protein kinase A

…, X Fang, ML Mohan, L Zhu, KC Tirupula… - Journal of Biological …, 2015 - ASBMB
Protein phosphorylation mediates essentially all aspects of cellular life. In humans, this is
achieved by ∼500 kinases, each recognizing a specific consensus motif (CM) in the substrates…