Cell volume-activated and volume-correlated anion channels in mammalian cells: their biophysical, molecular, and pharmacological properties

Y Okada, T Okada, K Sato-Numata, MR Islam… - Pharmacological …, 2019 - ASPET
There are a number of mammalian anion channel types associated with cell volume changes.
These channel types are classified into two groups: volume-activated anion channels (…

Roles of volume-regulatory anion channels, VSOR and Maxi-Cl, in apoptosis, cisplatin resistance, necrosis, ischemic cell death, stroke and myocardial infarction

Y Okada, T Numata, K Sato-Numata, RZ Sabirov… - Current Topics in …, 2019 - Elsevier
Two types of anion channels are directly activated by osmotic swelling and are involved in the
regulatory volume decrease (RVD) in most types of mammalian cells, and they include the …

[HTML][HTML] Cell death induction and protection by activation of ubiquitously expressed anion/cation channels. Part 1: roles of VSOR/VRAC in cell volume regulation …

Y Okada, RZ Sabirov, K Sato-Numata… - Frontiers in Cell and …, 2021 - frontiersin.org
Cell volume regulation (CVR) is essential for survival and functions of animal cells. Actually,
normotonic cell shrinkage and swelling are coupled to apoptotic and necrotic cell death and …

Distinct pharmacological and molecular properties of the acid-sensitive outwardly rectifying (ASOR) anion channel from those of the volume-sensitive outwardly …

K Sato-Numata, T Numata, R Inoue… - Pflügers Archiv-European …, 2016 - Springer
Expressed by many cell types, acid-sensitive outwardly rectifying (ASOR) anion channels are
known to be activated by extracellular acidification and involved in acidotoxic necrotic cell …

[HTML][HTML] Cell death induction and protection by activation of ubiquitously expressed anion/cation channels. Part 2: functional and molecular properties of ASOR/PAC …

Y Okada, K Sato-Numata, RZ Sabirov… - Frontiers in Cell and …, 2021 - frontiersin.org
For survival and functions of animal cells, cell volume regulation (CVR) is essential. Major
hallmarks of necrotic and apoptotic cell death are persistent cell swelling and shrinkage, and …

TRPM7 is involved in acid‐induced necrotic cell death in a manner sensitive to progesterone in human cervical cancer cells

T Numata, K SatoNumata, Y Okada - Physiological Reports, 2019 - Wiley Online Library
Because intravaginal pH is strongly acidic, it is important to investigate the effects of acidosis
on cervical cancer cells. Recently, in response to strong acidosis, human cervical cancer …

Acid-sensitive outwardly rectifying (ASOR) anion channels in human epithelial cells are highly sensitive to temperature and independent of ClC-3

K Sato-Numata, T Numata, T Okada… - Pflügers Archiv-European …, 2013 - Springer
A novel type of anion channel activated by extracellular acidification, called acid-sensitive
outwardly rectifying (ASOR) anion channel, was shown to be involved in acidotoxic necrotic …

[HTML][HTML] TRPM7 is an essential regulator for volume-sensitive outwardly rectifying anion channel

T Numata, K Sato-Numata, MC Hermosura… - Communications …, 2021 - nature.com
Animal cells can regulate their volume after swelling by the regulatory volume decrease (RVD)
mechanism. In epithelial cells, RVD is attained through KCl release mediated via volume-…

Temperature sensitivity of acid-sensitive outwardly rectifying (ASOR) anion channels in cortical neurons is involved in hypothermic neuroprotection against acidotoxic …

K Sato-Numata, T Numata, Y Okada - Channels, 2014 - Taylor & Francis
The acid-sensitive outwardly rectifying (ASOR) anion channel has been found in non-neuronal
cell types and was shown to be involved in acidotoxic death of epithelial cells. We have …

[HTML][HTML] A newly cloned ClC-3 isoform, ClC-3d, as well as ClC-3a mediates Cd2+-sensitive outwardly rectifying anion currents

T Okada, T Akita, K Sato-Numata, MR Islam… - Cellular Physiology and …, 2014 - karger.com
Background: ClC-3, a member of the ClC family, is predicted to have six isoforms, ClC-3a to-3f,
with distinct N-and C-terminal amino acid sequences. There have been conflicting …