The presence of an abnormal, protease‐resistant form of the prion protein (PrP) is the hallmark
of various forms of transmissible spongiform encephalopathies (TSE) which can affect a …

Mice heterozygous for the homeobox gene Engrailed-1 (En1) display progressive loss of
mesencephalic dopaminergic (mDA) neurons. We report that exogenous Engrailed-1 and …

Single O-linked N-acetylglucosamine (O-GlcNAc) sugar residues can compete with phosphate
groups to occupy specific sites on certain nuclear and cytosolic proteins. Here we show …

We examined the localization of PrP c in normal brain using free‐floating section
immunohistochemistry and monclonal antibody 3F4. In the mature hamster and baboon brain, PrP c …

Sonic hedgehog (SHH) is considered to play an important role in tissue induction and patterning
during development, particularly in determining neuronal cell fate in the ventral neural …

Engrailed 1 and engrailed 2 homeoprotein transcription factors (collectively Engrailed)
display graded expression in the chick optic tectum where they participate in retino-tectal …

PrP c , a sialoglycoprotein present in the normal adult hamster brain, is particularly abundant
in plastic brain regions but little is known about the level of expression and the localization …

Homeoproteins constitute a major class of transcription factors active throughout development
and in adulthood. Their membrane transduction properties were discovered over 20 years …

Retinal ganglion cells (RGCs) are the projection neurons from the eye to the brain and their
loss results in visual impairment in a number of diseases. Transcription factors with a …

The homeoprotein family comprises ~300 transcription factors and was long seen as
primarily involved in developmental programs through cell autonomous regulation. However, …