Organic synthesis on soluble polymer supports: liquid-phase methodologies

DJ Gravert, KD Janda - Chemical reviews, 1997 - ACS Publications
D. as an NSF graduate fellow under the direction of John H. Griffin. In 1995, he accepted a
postdoctoral position in the research group of Kim D. Janda at The Scripps Research Institute. …

Soluble polymer-supported organic synthesis

PH Toy, KD Janda - Accounts of chemical research, 2000 - ACS Publications
… He is currently a postdoctoral research associate at The Scripps Research Institute with
Professor Kim D. Janda, developing new resins for solid-phase organic synthesis. …

Catalytic antibodies

A Tramontano, KD Janda, RA Lerner - Science, 1986 - science.org
Monoclonal antibodies elicited to haptens that are analogs of the transition state for hydrolysis
of carboxylic esters behaved as enzymic catalysts with the appropriate substrates. These …

Linkage of recognition and replication functions by assembling combinatorial antibody Fab libraries along phage surfaces.

AS Kang, CF Barbas, KD Janda… - Proceedings of the …, 1991 - National Acad Sciences
We describe a method based on a phagemid vector with helper phage rescue for the construction
and rapid analysis of combinatorial antibody Fab libraries. This approach should allow …

Revisiting quorum sensing: Discovery of additional chemical and biological functions for 3-oxo-N-acylhomoserine lactones

…, AP Brogan, TJ Dickerson, KD Janda - Proceedings of the …, 2005 - National Acad Sciences
Bacteria use small diffusible molecules to exchange information in a process called quorum
sensing. An important class of autoinducers used by Gram-negative bacteria is the family of …

Antibody catalysis of the oxidation of water

…, IA Wilson, X Xu, WA Goddard III, KD Janda… - Science, 2001 - science.org
Recently we reported that antibodies can generate hydrogen peroxide (H 2 O 2 ) from singlet
molecular oxygen ( 1 O 2 *). We now show that this process is catalytic, and we identify the …

Soluble polymers as scaffolds for recoverable catalysts and reagents

TJ Dickerson, NN Reed, KD Janda - Chemical Reviews, 2002 - ACS Publications
… Since 2000, he has been a graduate student in Professor Kim D. Janda's laboratory. His
doctoral studies have focused on the design of novel solid-phase resins for use in combinatorial …

Polymer-supported catalysis in synthetic organic chemistry

B Clapham, TS Reger, KD Janda - Tetrahedron, 2001 - Elsevier
From the perspective of the organic chemist, the relevance of polymers has changed and
evolved dramatically over the past half century. From their early use in peptide and …

Evidence for antibody-catalyzed ozone formation in bacterial killing and inflammation

…, T Jones, C Bautista, JM Ruedi, A Gutierrez, KD Janda… - Science, 2002 - science.org
Recently, we showed that antibodies catalyze the generation of hydrogen peroxide (H 2 O 2
) from singlet molecular oxygen ( 1 O 2 *) and water. Here, we show that this process can …

Evidence for ozone formation in human atherosclerotic arteries

…, GA DeLaria, A Saven, BM Babior, KD Janda… - Science, 2003 - science.org
Here, we report evidence for the production of ozone in human disease. Signature products
unique to cholesterol ozonolysis are present within atherosclerotic tissue at the time of …