The Concise Guide to PHARMACOLOGY 2019/20: G protein‐coupled receptors

…, DL Segaloff, CN Serhan, LA Stoddart… - British journal of …, 2019 - Wiley Online Library
The Concise Guide to PHARMACOLOGY 2019/20 is the fourth in this series of biennial
publications. The Concise Guide provides concise overviews of the key properties of nearly 1800 …

International Union of Pharmacology. LXXI. Free fatty acid receptors FFA1,-2, and-3: pharmacology and pathophysiological functions

LA Stoddart, NJ Smith, G Milligan - Pharmacological reviews, 2008 - ASPET
Identification of G protein-coupled receptors that are activated by free fatty acids has led to
considerable interest in their pharmacology and function because of the wide range of normal …

The concise guide to PHARMACOLOGY 2015/16: Overview

…, FM Sladek, G Stewart, LA Stoddart… - British journal of …, 2015 - Wiley Online Library
The Concise Guide to PHARMACOLOGY 2015/16 provides concise overviews of the key
properties of over 1750 human drug targets with their pharmacology, plus links to an open …

[HTML][HTML] Range management.

LA Stoddart, AD Smith - 1955 - cabidigitallibrary.org
This book was originally published during the war and consequently the first edition is little
known in Britain. From the number of pages and chapters, it would appear that the new …

The Concise Guide to PHARMACOLOGY 2021/22: G protein‐coupled receptors

…, DL Segaloff, CN Serhan, LA Stoddart… - British journal of …, 2021 - Wiley Online Library
The Concise Guide to PHARMACOLOGY 2021/22 is the fifth in this series of biennial
publications. The Concise Guide provides concise overviews, mostly in tabular format, of the key …

Application of BRET to monitor ligand binding to GPCRs

LA Stoddart, EKM Johnstone, AJ Wheal, J Goulding… - Nature …, 2015 - nature.com
Bioluminescence resonance energy transfer (BRET) is a well-established method for
investigating protein-protein interactions. Here we present a BRET approach to monitor ligand …

Kinetics for Drug Discovery: an industry-driven effort to target drug residence time

…, M Amaral, D Guo, D Andres, V Georgi, LA Stoddart… - Drug Discovery …, 2017 - Elsevier
Highlights • A public–private partnership targets drug-binding kinetics in a multilevel
approach. • New experimental approaches for measuring drug residence time are presented. • …

Fluorescence‐and bioluminescence‐based approaches to study GPCR ligand binding

LA Stoddart, CW White, K Nguyen… - British journal of …, 2016 - Wiley Online Library
… Leigh A Stoddart … and quantification of levels of bound fluorescent ligand have been
successfully applied in both competition (Stoddart et al., 2012; Vernall et al., 2013; Gherbi et al., 2014…

[HTML][HTML] Binding kinetics of ligands acting at GPCRs

DA Sykes, LA Stoddart, LE Kilpatrick, SJ Hill - Molecular and cellular …, 2019 - Elsevier
The influence of drug-receptor binding kinetics has often been overlooked during the
development of new therapeutics that target G protein-coupled receptors (GPCRs). Over the last …

[HTML][HTML] Conserved polar residues in transmembrane domains V, VI, and VII of free fatty acid receptor 2 and free fatty acid receptor 3 are required for the binding and …

LA Stoddart, NJ Smith, L Jenkins, AJ Brown… - Journal of biological …, 2008 - ASBMB
FFA2 and FFA3 are closely related G protein-coupled receptors that bind and respond to
short chain fatty acids. (FFA2 and FFA3 are the provisional International Union of …