▪ Abstract The blood-brain barrier (BBB) is formed by brain capillary endothelial cells (ECs).
In the late embryonic and early postnatal period, these cells respond to inducing factors …

Several key signalling pathways, such as Hedgehog, Notch, Wnt and BMP–TGFβ–Activin (bone
morphogenetic protein–transforming growth factor-β–Activin), are involved in most …

Growth differentiation factor 11 (GDF11) and myostatin (or GDF8) are closely related members
of the transforming growth factor β superfamily and are often perceived to serve similar or …

Ligand-dependent activation of the hedgehog (Hh) signalling pathway has been associated
with tumorigenesis in a number of human tissues 1 , 2 , 3 , 4 , 5 , 6 , 7 . Here we show that, …

In the adult central nervous system, the vasculature of the neurogenic niche regulates neural
stem cell behavior by providing circulating and secreted factors. Age-related decline of …

… Bard and LL Rubin, unpublished observations) . In this paper, we describe a method that
utilizes … Marazzi, and LL Rubin. 1988. A molecular defect in virally transformed muscle cells that …

The combined activity of three transcription factors can reprogram adult cells into induced
pluripotent stem cells (iPSCs). However, the transgenic methods used for delivering …

Sympathetic neurons depend on nerve growth factor (NGF) for survival and die by apoptosis
in its absence. We have investigated the pattern of expression of the Jun and Fos family of …

To directly test the requirement for hedgehog signaling in the telencephalon from early
neurogenesis, we examined conditional null alleles of both the Sonic hedgehog and …

… are subject to regulation by a variety of cytoplasmic signalling systems (Staddon and Rubin,
… (ACM) were prepared essentially as described by Rubin et al. (1991). Culture medium for …