The enzymatic activities of CD39 and CD73 play strategic roles in calibrating the duration,
magnitude, and chemical nature of purinergic signals delivered to immune cells through the …

Cancer is a complex disease that is dictated by both cancer cell-intrinsic and cell-extrinsic
processes. Adenosine is an ancient extracellular signalling molecule that can regulate almost …

Over recent years, significant advances in cancer immunotherapy have been made due to a
better understanding of the principles underlying tumor biology and immunology. In this …

Objectives : The aim of this study was to assess the long-term prognostic role of multidetector
computed tomography coronary angiography (CTA) in patients with suspected coronary …

Neurological diseases, such as Parkinson’s disease, Alzheimer’s disease, amyotrophic
lateral sclerosis (ALS) and multiple sclerosis, are often associated with functional …

Several lines of evidence point out the relevance of nucleotide-binding oligomerization domain
leucine rich repeat and pyrin domain-containing protein 3 (NLRP3) inflammasome as a …

… Other studies have confirmed the beneficial effects of A 1 blockade on allergen-induced
bronchoconstriction by showing the efficacy of L-97-1 (3-[2-(4-aminophenyl)-ethyl]-8-benzyl-7-{2-…

… 1 adenosine receptor agonist, N 6 -L-phenyl-isopropyl-adenosine (L-PIA). This finding was
… which also demonstrated that the inhibitory action of L-PIA on insulin release was attributable …

The intestinal barrier, which primarily consists of a mucus layer, an epithelial barrier, and a
gut vascular barrier, has a crucial role in health and disease by facilitating nutrient absorption …

The adenosine pathway is a powerful evolutionarily selected mechanism aimed at a fine
modulation of inflammatory responses and protection of tissues from injuries. Adenosine exerts …