User profiles for L. Gabriel Navar

LuisGabriel Navar

Professor and Chair, Dept of Physiology, Tulane University School of Medicine
Verified email at tulane.edu
Cited by 29367

The intrarenal renin-angiotensin system: from physiology to the pathobiology of hypertension and kidney disease

H Kobori, M Nangaku, LG Navar, A Nishiyama - Pharmacological reviews, 2007 - ASPET
In recent years, the focus of interest on the role of the renin-angiotensin system (RAS) in the
pathophysiology of hypertension and organ injury has changed to a major emphasis on the …

Regulation of intrarenal angiotensin II in hypertension

LG Navar, LM Harrison-Bernard, A Nishiyama… - …, 2002 - Am Heart Assoc
Intrarenal angiotensin II (Ang II) is regulated by several complex processes involving formation
from both systemically delivered and intrarenally formed substrate, as well as receptor-…

[HTML][HTML] Urinary excretion of angiotensinogen reflects intrarenal angiotensinogen production

H Kobori, LM Harrison-Bernard, LG Navar - Kidney international, 2002 - Elsevier
… After decapitation, trunk blood was collected into chilled tubes containing EDTA (5 mmol/L),
enalaprilat (20 μmol/L), pepstatin A (10 μmol/L), and 1,10-phenanthroline (1.25 mmol/…

Enhancement of intrarenal angiotensinogen in Dahl salt-sensitive rats on high salt diet

H Kobori, A Nishiyama, Y Abe, LG Navar - Hypertension, 2003 - Am Heart Assoc
This study was performed to examine whether there is an inappropriate regulation of
intrarenal angiotensinogen in Dahl-salt sensitive rats (DS) fed a high salt diet (HS). Dahl salt-…

Urinary angiotensinogen as an indicator of intrarenal angiotensin status in hypertension

…, A Nishiyama, LM Harrison-Bernard, LG Navar - …, 2003 - Am Heart Assoc
Angiotensin II (AngII) infusions augment renal angiotensinogen mRNA and protein and urinary
angiotensinogen excretion (U AGT ). Further experiments were performed in 4 groups of …

Immunohistochemical localization of ANG II AT1 receptor in adult rat kidney using a monoclonal antibody

LM Harrison-Bernard, LG Navar… - American Journal …, 1997 - journals.physiology.org
Molecular and functional studies have suggested that AT1 receptors are present in most
nephron segments, yet direct demonstration of AT1 at these sites is lacking. The present study …

Intratubular renin-angiotensin system in hypertension

LG Navar, H Kobori, MC Prieto… - …, 2011 - Am Heart Assoc
The complexity of the intrarenal renin-angiotensin (Ang) system (RAS) continues to reveal
itself as evidence accumulates demonstrating its robust independent regulation in the …

Renal interstitial fluid concentrations of angiotensins I and II in anesthetized rats

A Nishiyama, DM Seth, LG Navar - Hypertension, 2002 - Am Heart Assoc
Previous studies have indicated that angiotensin II (Ang II) concentrations in renal interstitial
fluid are much higher than plasma levels. In the present study, we performed experiments to …

Expression of angiotensinogen mRNA and protein in angiotensin II-dependent hypertension

…, LM Harrison-Bernard, LG Navar - Journal of the American …, 2001 - journals.lww.com
Chronic elevations in circulating angiotensin II (AngII) levels produce sustained hypertension
and increased intrarenal AngII contents through multiple mechanisms, which may include …

Enhancement of collecting duct renin in angiotensin II–dependent hypertensive rats

…, Y Ozawa, KS Hering-Smith, LL Hamm, LG Navar - …, 2004 - Am Heart Assoc
Distal nephron renin may provide a possible pathway for angiotensin (Ang) I generation from
proximally delivered angiotensinogen. To examine the effects of Ang II on distal nephron …