Hyperpolarization-activated, cyclic nucleotide–gated (HCN) channels are important members
of the voltage-gated pore loop channels family. They show unique features: they open at …

Cardiomyocytes derived from human embryonic stem cells constitute a promising cell
source for the regeneration of damaged hearts. The assessment of their in vitro functional …

Background— Hypertrophic cardiomyopathy (HCM), the most common mendelian heart
disorder, remains an orphan of disease-specific pharmacological treatment because of the …

Hyperpolarization-activated, cyclic nucleotide-gated (HCN) channels, the molecular correlate
of the hyperpolarization-activated current (If/Ih), are membrane proteins which play an …

In-depth characterization of heart-brain communication in critically ill patients with severe
acute respiratory failure is attracting significant interest in the COronaVIrus Disease 19 (COVID-…

Acetaminophen [N‐acetyl‐p‐aminophenol (APAP)] is the most common antipyretic/analgesic
medicine worldwide. If APAP is overdosed, its metabolite, N‐acetyl‐p‐benzo‐…

The pacemaker current I f is present in ventricular myocytes from the human failing heart where
it may contribute to arrhythmogenesis. The role of cardiac disease in the modulation of I f …

Objective: I f is a hyperpolarization-activated current, which plays a key role in determining
the spontaneous rate of cardiac pacemaker cells. We have previously shown that I f is also …

HL‐1 cells are adult mouse atrial myocytes induced to proliferate indefinitely by SV40 large
T antigen. These cells beat spontaneously when confluent and express several adult cardiac …

Although several antiarrhythmic drugs of chemical origin are in clinical use since decades,
their application is often limited by their adverse effects and especially by their inherited …