User profiles for Lauren A. Biwer

Lauren A. Biwer

Assistant Professor, Yale School of Medicine
Verified email at yale.edu
Cited by 641

Regulation of cellular communication by signaling microdomains in the blood vessel wall

M Billaud, AW Lohman, SR Johnstone, LA Biwer… - Pharmacological …, 2014 - ASPET
It has become increasingly clear that the accumulation of proteins in specific regions of the
plasma membrane can facilitate cellular communication. These regions, termed signaling …

Loss of endothelial FTO antagonizes obesity-induced metabolic and vascular dysfunction

N Krüger, LA Biwer, ME Good, CA Ruddiman… - Circulation …, 2020 - Am Heart Assoc
Rationale: Increasing prevalence of obesity and its associated risk with cardiovascular
diseases demands a better understanding of the contribution of different cell types within this …

A venous-specific purinergic signaling cascade initiated by Pannexin 1 regulates TNFα-induced increases in endothelial permeability

…, CA Ruddiman, YL Chen, X Chen, LA Biwer… - Science …, 2021 - science.org
The endothelial cell barrier regulates the passage of fluid between the bloodstream and
underlying tissues, and barrier function impairment exacerbates the severity of inflammatory …

Smooth muscle mineralocorticoid receptor promotes hypertension after preeclampsia

LA Biwer, Q Lu, J Ibarrola, A Stepanian… - Circulation …, 2023 - Am Heart Assoc
Background: Preeclampsia is a syndrome of high blood pressure (BP) with end organ damage
in late pregnancy that is associated with high circulating soluble VEGF receptor (sFlt1 […

[HTML][HTML] Endothelial cell α-globin and its molecular chaperone α-hemoglobin–stabilizing protein regulate arteriolar contractility

…, JT Butcher, A Freiwan, LA Biwer… - The Journal of …, 2018 - Am Soc Clin Investig
Arteriolar endothelial cell–expressed (EC-expressed) α-globin binds endothelial NOS (eNOS)
and degrades its enzymatic product, NO, via dioxygenation, thereby lessening the …

Mineralocorticoid receptor in smooth muscle contributes to pressure overload–induced heart failure

SK Kim, LA Biwer, ME Moss, JJ Man… - Circulation: Heart …, 2021 - Am Heart Assoc
Background: Mineralocorticoid receptor (MR) antagonists decrease heart failure (HF)
hospitalization and mortality, but the mechanisms are unknown. Preclinical studies reveal that the …

Two functionally distinct pools of eNOS in endothelium are facilitated by myoendothelial junction lipid composition

LA Biwer, EP Taddeo, BM Kenwood, KL Hoehn… - … et Biophysica Acta (BBA …, 2016 - Elsevier
In resistance arteries, endothelial cells (EC) make contact with smooth muscle cells (SMC),
forming myoendothelial junctions (MEJ). Endothelial nitric oxide synthase (eNOS) is present …

Vascular mineralocorticoid receptor: evolutionary mediator of wound healing turned harmful by our modern lifestyle

LA Biwer, MC Wallingford, IZ Jaffe - American Journal of …, 2019 - academic.oup.com
The mineralocorticoid receptor (MR) is indispensable for survival through its critical role in
maintaining blood pressure in response to sodium scarcity or bleeding. Activation of MR by …

Mineralocorticoid and estrogen receptors in endothelial cells coordinately regulate microvascular function in obese female mice

LA Biwer, BV Carvajal, Q Lu, JJ Man, IZ Jaffe - Hypertension, 2021 - Am Heart Assoc
Obesity impairs endothelial-mediated vasodilation, the earliest step in vascular disease and
a contributor to hypertension. We previously demonstrated that endothelial cell MR (…

Non–endoplasmic reticulum–based calr (calreticulin) can coordinate heterocellular calcium signaling and vascular function

LA Biwer, ME Good, K Hong, RK Patel… - … , and vascular biology, 2018 - Am Heart Assoc
Objective— In resistance arteries, endothelial cell (EC) extensions can make contact with
smooth muscle cells, forming myoendothelial junction at holes in the internal elastic lamina (…