The Concise Guide to PHARMACOLOGY 2021/22: G protein‐coupled receptors

…, DL Segaloff, CN Serhan, LA Stoddart… - British journal of …, 2021 - Wiley Online Library
The Concise Guide to PHARMACOLOGY 2021/22 is the fifth in this series of biennial
publications. The Concise Guide provides concise overviews, mostly in tabular format, of the key …

The Concise Guide to PHARMACOLOGY 2019/20: G protein‐coupled receptors

…, DL Segaloff, CN Serhan, LA Stoddart… - British journal of …, 2019 - Wiley Online Library
The Concise Guide to PHARMACOLOGY 2019/20 is the fourth in this series of biennial
publications. The Concise Guide provides concise overviews of the key properties of nearly 1800 …

International Union of Pharmacology. LXXI. Free fatty acid receptors FFA1,-2, and-3: pharmacology and pathophysiological functions

LA Stoddart, NJ Smith, G Milligan - Pharmacological reviews, 2008 - ASPET
Identification of G protein-coupled receptors that are activated by free fatty acids has led to
considerable interest in their pharmacology and function because of the wide range of normal …

Application of BRET to monitor ligand binding to GPCRs

LA Stoddart, EKM Johnstone, AJ Wheal, J Goulding… - Nature …, 2015 - nature.com
Bioluminescence resonance energy transfer (BRET) is a well-established method for
investigating protein-protein interactions. Here we present a BRET approach to monitor ligand …

Kinetics for Drug Discovery: an industry-driven effort to target drug residence time

…, M Amaral, D Guo, D Andres, V Georgi, LA Stoddart… - Drug Discovery …, 2017 - Elsevier
… Heitman 5 , Elena Segala 6 , Marta Amaral 7 10 , Dong Guo 5 , Dorothee Andres 8 , Victoria
Georgi 8 , Leigh A. Stoddart 9 , Steve Hill 9 , Robert M. Cooke 6 , Chris De Graaf 4 , Rob …

Fluorescence‐and bioluminescence‐based approaches to study GPCR ligand binding

LA Stoddart, CW White, K Nguyen… - British journal of …, 2016 - Wiley Online Library
Ligand binding is a vital component of any pharmacologist's toolbox and allows the detailed
investigation of how a molecule binds to its receptor. These studies enable the experimental …

[HTML][HTML] Conserved polar residues in transmembrane domains V, VI, and VII of free fatty acid receptor 2 and free fatty acid receptor 3 are required for the binding and …

LA Stoddart, NJ Smith, L Jenkins, AJ Brown… - Journal of biological …, 2008 - ASBMB
FFA2 and FFA3 are closely related G protein-coupled receptors that bind and respond to
short chain fatty acids. (FFA2 and FFA3 are the provisional International Union of …

[HTML][HTML] Binding kinetics of ligands acting at GPCRs

DA Sykes, LA Stoddart, LE Kilpatrick, SJ Hill - Molecular and cellular …, 2019 - Elsevier
The influence of drug-receptor binding kinetics has often been overlooked during the
development of new therapeutics that target G protein-coupled receptors (GPCRs). Over the last …

[HTML][HTML] Probing the pharmacology of G protein-coupled receptors with fluorescent ligands

LA Stoddart, LE Kilpatrick, SJ Briddon, SJ Hill - Neuropharmacology, 2015 - Elsevier
G protein-coupled receptors control a wide range of physiological processes and are the
target for many clinically used drugs. Understanding the way in which receptors bind agonists …

NanoBRET approaches to study ligand binding to GPCRs and RTKs

LA Stoddart, LE Kilpatrick, SJ Hill - Trends in pharmacological sciences, 2018 - cell.com
Recent advances in the development of fluorescent ligands for G-protein-coupled receptors
(GPCRs) and receptor tyrosine kinase receptors (RTKs) have facilitated the study of these …