The importance of membrane transporters for drug pharmacokinetics has been increasingly
recognized during the last decade. Organic anion transporting polypeptide 1B1 (OATP1B1) …

Methods Four healthy volunteers with the homozygous SLCO1B1 c. 521CC genotype, 12
with the heterozygous c. 521TC genotype and 16 with the homozygous c. 521TT genotype (…

Thirty‐two healthy volunteers with different SLCO1B1 genotypes ingested a 20 mg dose of
atorvastatin and 10 mg dose of rosuvastatin with a washout period of 1 week. Subjects with …

Objective Pravastatin is a hydrophilic substrate and fluvastatin a lipophilic substrate of the
hepatic uptake transporter organic anion transporting polypeptide 1B1 encoded by SLCO1B1. …

Introduction: Organic anion transporting polypeptide 1B1 (OATP1B1), encoded by the
SLCO1B1 gene, mediates the hepatic uptake of endogenous compounds and xenobiotics, …

Aims: This study aimed to investigate possible effects of the ABCG2 c.421C>A (p.Gln141Lys;
rs2231142) genotype on fluvastatin, pravastatin and simvastatin pharmacokinetics. …

Objective Organic anion transporting polypeptide 1B1 (OATP1B1) is a drug uptake
transporter located at the sinusoidal membrane of hepatocytes. Our aim was to establish high-…

Objective Our aim was to investigate possible effects of sequence variations in ABCC2,
encoding the multidrug resistance-associated protein 2 (MRP2), on the pharmacokinetics of the …

Objective Loperamide is biotransformed in vitro by the cytochromes P450 (CYP) 2C8 and
3A4 and is a substrate of the P-glycoprotein efflux transporter. Our aim was to investigate the …

Methods Fasting blood samples were drawn from 24 healthy volunteers with SLCO1B1 c.
388AA-c. 521TT (* 1A/* 1A) genotype, eight with c. 388GG-c. 521TT (* 1B/* 1B) genotype, 24 …